Modified Guilu Erxian Glue regulates Treg immune function to suppress bone marrow failure in aplastic anemia mice
Compared with the IST + EP or IST alone, the combination treatment of IST + MGEG further improved hematopoietic function in AA mice. These effects should involve regulating the differentiation of Treg cells through intervening in the activation of IL-2/STAT5 signaling pathway, improving the immune regulatory function of Treg cells by intervening in the miR-17-5p/Eos signaling pathway, and inhibiting Fas/FasL mediated apoptosis.
Authors
- Weihua Gao (ORCID: https://orcid.org/0000-0002-2342-0708)
- Pingxin Zhang
- Yingkai Zhang (ORCID: https://orcid.org/0000-0002-4984-3354)
- Jingmin Niu
- Limin Chai (ORCID: https://orcid.org/0000-0002-9207-1169)
- Boyang Meng (ORCID: https://orcid.org/0000-0003-1418-7374)
- Wei Liu (ORCID: https://orcid.org/0000-0001-9439-5100)
- Song Sun
- Jinghao Sang
Institutions
- Beijing University of Chinese Medicine (CN)
- Dongzhimen Hospital Affiliated to Beijing University of Chinese Medicine (CN)
Publication Details
- Journal
- Chinese Medicine
- Published
- 2025-11-20
- DOI
- https://doi.org/10.1186/s13020-025-01266-z
- Citations
- 1
- Primary Topic
- Exercise and Physiological Responses
- Type
- article
- Field-Weighted Citation Impact
- 1.03
Funders
- National Natural Science Foundation of China