Monocyte iron load correlates with immune suppression and sepsis severity: A longitudinal analysis
The study highlights that early iron accumulation in monocytes is a hallmark of sepsis and is closely linked to disease severity and progression. We expect that improved insights into iron metabolism in sepsis patients may pave the way to improving therapeutic options that balance iron levels and their effects on organ functions in the future.
Authors
- Christina Mertens (ORCID: https://orcid.org/0000-0002-0767-4759)
- Judith Schenz (ORCID: https://orcid.org/0000-0002-6771-8864)
- Anna Hafner (ORCID: https://orcid.org/0000-0002-3410-0371)
- Mascha O. Fiedler (ORCID: https://orcid.org/0000-0002-0127-2783)
- Christoph Kahlert (ORCID: https://orcid.org/0000-0003-4124-7918)
- Martina U. Muckenthaler
- Dania Fischer (ORCID: https://orcid.org/0000-0003-2086-0107)
- Markus Weigand (ORCID: https://orcid.org/0000-0002-0325-2268)
- R. Anand (ORCID: https://orcid.org/0000-0002-0588-076X)
- D. A. Reuter
- Bastian Winkelhausen
Institutions
- Heidelberg University (DE)
- University Hospital Heidelberg (DE)
- German Center for Lung Research (DE)
Publication Details
- Journal
- Journal of Infection
- Published
- 2025-11-20
- DOI
- https://doi.org/10.1016/j.jinf.2025.106660
- Primary Topic
- Iron Metabolism and Disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Deutsche Forschungsgemeinschaft