CLOCK-mediated acetylation of NF-κB p65 drives immune evasion in breast cancer
CLOCK functions as a critical prognostic biomarker in BC by promoting tumor proliferation, chemoresistance, and immune evasion. Mechanistically, CLOCK mediates NF-κB p65 acetylation to enhance PD-L1 transcription, promoting immune evasion in BC.
Authors
- Yixin Duan
- Xinyu Quan
- Na Li (ORCID: https://orcid.org/0000-0002-7850-2671)
- Jie Huang (ORCID: https://orcid.org/0000-0003-0381-1549)
Institutions
- Qingdao University (CN)
- Nanjing University of Chinese Medicine (CN)
- Westlake University (CN)
- Affiliated Hangzhou First People's Hospital, Westlake University, School of Medicine (CN)
- Hangzhou Cancer Hospital (CN)
- Ocean University of China (CN)
Publication Details
- Journal
- Biology Direct
- Published
- 2025-11-20
- DOI
- https://doi.org/10.1186/s13062-025-00704-0
- Primary Topic
- NF-κB Signaling Pathways
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- China Postdoctoral Science Foundation
- Natural Science Foundation of Shandong Province