Association of human papillomavirus on risk of HIV acquisition in African women: analyses from MTN-020/ASPIRE
HPV clearance-related immune activation is strongly linked to HIV acquisition, likely due to increased CD4+ T cells and inflammation. These findings support HPV vaccination as a potential HIV prevention strategy and highlight the need to integrate HIV prevention into cervical cancer programs.
Authors
- Christine Hathaway (ORCID: https://orcid.org/0009-0006-7332-1480)
- Ruanne V. Barnabas (ORCID: https://orcid.org/0000-0002-1793-6003)
- Nishanta Singh
- Zakir Gaffoor
- Nitesha Jeenarain
- Nelly Mugo (ORCID: https://orcid.org/0000-0002-2347-006X)
- Samantha Siva
- Zvavahera M. Chirenje (ORCID: https://orcid.org/0000-0003-3538-5150)
- Ailton Sepulveda (ORCID: https://orcid.org/0000-0001-9559-4742)
- Kubashni Woeber
- Thesla Palanee‐Phillips (ORCID: https://orcid.org/0000-0002-0052-5830)
- Leila E. Mansoor (ORCID: https://orcid.org/0000-0002-7607-348X)
- Flavia Matovu Kiweewa (ORCID: https://orcid.org/0000-0002-0046-4353)
- Brenda Gati Mirembe (ORCID: https://orcid.org/0000-0001-9074-6751)
- Sufia Dadabhai (ORCID: https://orcid.org/0000-0002-4965-1440)
- Elizabeth R. Brown (ORCID: https://orcid.org/0000-0003-4286-2111)
- Lameck Chinula
- Stephen Cherne
- Logashvari Naidoo (ORCID: https://orcid.org/0000-0003-3766-7370)
Institutions
- South African Medical Research Council (ZA)
- University of North Carolina at Chapel Hill (US)
- Bloomberg (United States) (US)
- Harvard University (US)
- Johns Hopkins University (US)
- University of Zimbabwe (ZW)
- University of Malawi (MW)
- University of California, San Francisco (US)
- University of the Witwatersrand (ZA)
- University of Washington (US)
- Centre for the AIDS Programme of Research in South Africa (ZA)
- Kamuzu Central Hospital (MW)
- The University of Texas Rio Grande Valley (US)
- Harborview Medical Center (US)
- Kenya Medical Research Institute (KE)
- Massachusetts General Hospital (US)
- Reproductive Science Center (US)
- Fred Hutch Cancer Center (US)
- Cancer Research And Biostatistics (US)
- Lilongwe University of Agriculture and Natural Resources (MW)
- MUJHU Research Collaboration (UG)
- Kamuzu University of Health Sciences (MW)
- University of San Francisco (US)
- University of KwaZulu-Natal (ZA)
Publication Details
- Journal
- JNCI Journal of the National Cancer Institute
- Published
- 2025-11-15
- DOI
- https://doi.org/10.1093/jnci/djaf336
- Citations
- 1
- Primary Topic
- Cervical Cancer and HPV Research
- Type
- article
- Field-Weighted Citation Impact
- 1.35