A framework for using DNA methylation-based modelling for the clinical management of cranial meningioma
We identify methylation-defined risk groups of meningioma for which additional benefit is gained from adjuvant RT, leading to a clinical decision-making framework for straightforward integration of molecular models into clinical practice.
Authors
- Bianca Pollo (ORCID: https://orcid.org/0000-0002-5523-4256)
- Mirjam Renovanz (ORCID: https://orcid.org/0000-0002-2824-3720)
- Sybren L. N. Maas (ORCID: https://orcid.org/0000-0002-8745-4405)
- Luke Hnenny
- Aditya Raghunathan (ORCID: https://orcid.org/0000-0001-6198-7441)
- Jennifer Moliterno (ORCID: https://orcid.org/0000-0002-6413-5874)
- Jeff Liu (ORCID: https://orcid.org/0000-0002-9928-7552)
- Farshad Nassiri (ORCID: https://orcid.org/0000-0002-0797-3425)
- Bryan J. Neth (ORCID: https://orcid.org/0000-0003-2342-0000)
- Tiit Illimar Mathiesen (ORCID: https://orcid.org/0000-0001-9463-1919)
- David Ronan Raleigh (ORCID: https://orcid.org/0000-0001-9299-8864)
- Paul C. Boutros (ORCID: https://orcid.org/0000-0003-0553-7520)
- Craig Horbinski (ORCID: https://orcid.org/0000-0001-8340-9992)
- Maximilian Deng (ORCID: https://orcid.org/0000-0003-4925-7600)
- Tobias Greve (ORCID: https://orcid.org/0000-0003-2973-5687)
- Aaron Cohen‐Gadol (ORCID: https://orcid.org/0000-0002-4946-1524)
- Vikas Patil
- Quinn T. Ostrom (ORCID: https://orcid.org/0000-0003-3469-7558)
- Maciej M. Mrugała (ORCID: https://orcid.org/0000-0002-4027-7173)
- Priscilla Kaliopi Brastianos (ORCID: https://orcid.org/0000-0003-4470-8425)
- Viktor Zherebitskiy
- James A. Balogun (ORCID: https://orcid.org/0000-0002-0737-5265)
- Jana Ivanidze (ORCID: https://orcid.org/0000-0002-6470-5400)
- Michael Weller (ORCID: https://orcid.org/0000-0002-1748-174X)
- Evanthia Galanis (ORCID: https://orcid.org/0000-0001-8014-786X)
- Katrin Lamszus (ORCID: https://orcid.org/0000-0002-1381-2353)
- Roland Goldbrunner (ORCID: https://orcid.org/0000-0002-1927-0022)
- Mark W. Youngblood (ORCID: https://orcid.org/0000-0002-1044-8015)
- Richard G. Everson (ORCID: https://orcid.org/0000-0003-2809-3061)
- Patrick Yung Wen (ORCID: https://orcid.org/0000-0002-0774-7700)
- Christel C. Herold‐Mende (ORCID: https://orcid.org/0000-0002-1915-745X)
- Christian la Fougère (ORCID: https://orcid.org/0000-0001-7519-0417)
- Tobias Walbert (ORCID: https://orcid.org/0000-0003-0667-8106)
- Francesco DiMeco (ORCID: https://orcid.org/0000-0001-6213-5793)
- Carolina Benjamin (ORCID: https://orcid.org/0000-0001-8134-7943)
- Deva S. Jeyaretna (ORCID: https://orcid.org/0000-0001-7812-5995)
- Christian Mawrin (ORCID: https://orcid.org/0000-0002-6677-3124)
- Andrew Morokoff (ORCID: https://orcid.org/0000-0002-5159-3438)
- Olivia Singh
- Laura Fariselli (ORCID: https://orcid.org/0000-0003-1329-4530)
- Felix Behling (ORCID: https://orcid.org/0000-0002-1083-1276)
- Chloe Gui (ORCID: https://orcid.org/0000-0002-6685-1970)
- Joshua D. Palmer (ORCID: https://orcid.org/0000-0003-3311-0129)
- Philipp Karschnia (ORCID: https://orcid.org/0000-0002-1254-5310)
- Yazmín Odia (ORCID: https://orcid.org/0000-0003-3602-3899)
- Minesh P. Mehta (ORCID: https://orcid.org/0000-0002-4812-5713)
- Rafael Martínez-Pérez (ORCID: https://orcid.org/0000-0002-2896-2346)
- David Capper (ORCID: https://orcid.org/0000-0003-1945-497X)
- Christian Schichor (ORCID: https://orcid.org/0000-0001-6684-3578)
- Katharine J. Drummond (ORCID: https://orcid.org/0000-0002-8152-2120)
- Evan Calabrese (ORCID: https://orcid.org/0000-0002-1464-0354)
- Jens Schittenhelm (ORCID: https://orcid.org/0000-0002-9168-6209)
- Marco Timmer (ORCID: https://orcid.org/0000-0002-8790-9617)
- Leeor Yefet
- Michelle M. Felicella (ORCID: https://orcid.org/0000-0003-0872-5113)
- Marcos Soares Tatagiba (ORCID: https://orcid.org/0000-0002-1627-9937)
- Stephen Yip (ORCID: https://orcid.org/0000-0002-8514-9861)
- C. Oliver Hanemann (ORCID: https://orcid.org/0000-0002-1951-1025)
- Helen Alice Shih (ORCID: https://orcid.org/0000-0003-1550-9726)
- Daniele Scartoni
- Wenya Linda Bi (ORCID: https://orcid.org/0000-0002-4635-0247)
- Norbert Galldiks (ORCID: https://orcid.org/0000-0002-2485-1796)
- Clinton P. Turner (ORCID: https://orcid.org/0000-0002-2138-7633)
- Kyle M. Walsh (ORCID: https://orcid.org/0000-0002-5879-9981)
- Daniel H. Lachance (ORCID: https://orcid.org/0000-0002-5475-9931)
- Nico Teske (ORCID: https://orcid.org/0000-0002-7153-7994)
- Derek S. Tsang (ORCID: https://orcid.org/0000-0002-9762-6901)
- Jill S. Barnholtz‐Sloan (ORCID: https://orcid.org/0000-0001-6190-9304)
- Alireza Mansouri (ORCID: https://orcid.org/0000-0002-7442-7539)
- Serge Makarenko (ORCID: https://orcid.org/0000-0002-6283-249X)
- Andreas von Deimling (ORCID: https://orcid.org/0000-0002-5863-540X)
- Arie Perry (ORCID: https://orcid.org/0000-0002-8300-7261)
- Christina Arvaniti (ORCID: https://orcid.org/0000-0001-9488-772X)
- Andrew Ajisebutu
- Erik P. Sulman (ORCID: https://orcid.org/0000-0003-4933-9120)
- Justin Z. Wang (ORCID: https://orcid.org/0000-0001-8998-7443)
- Yasin Mamatjan (ORCID: https://orcid.org/0000-0002-8807-2927)
- Karolyn Au (ORCID: https://orcid.org/0000-0001-5536-2971)
- Timothy J. Kaufmann (ORCID: https://orcid.org/0000-0001-7483-1569)
- Michael D. Jenkinson (ORCID: https://orcid.org/0000-0003-4587-2139)
- Ana Valéria Castro (ORCID: https://orcid.org/0000-0003-0417-0210)
- William Muirhead (ORCID: https://orcid.org/0000-0001-7163-0120)
- Kenneth Aldape (ORCID: https://orcid.org/0000-0001-5119-7550)
- Cristina Matesanz López (ORCID: https://orcid.org/0000-0001-6380-4282)
- Gerhard Jungwirth (ORCID: https://orcid.org/0000-0001-7571-8947)
- Felix Sahm (ORCID: https://orcid.org/0000-0001-5441-1962)
- Manfred Westphal (ORCID: https://orcid.org/0000-0003-3483-6335)
- Michael E. Ivan (ORCID: https://orcid.org/0000-0002-4798-4989)
- Raymond Y. Huang (ORCID: https://orcid.org/0000-0001-7661-797X)
- Yosef Ellenbogen (ORCID: https://orcid.org/0000-0003-1390-1361)
- Dante Amelio (ORCID: https://orcid.org/0000-0002-0566-1268)
- Thomas Santarius (ORCID: https://orcid.org/0000-0002-1416-9566)
- Daniel M. Fountain (ORCID: https://orcid.org/0000-0001-6227-9930)
- Marta Couce (ORCID: https://orcid.org/0000-0002-9595-2586)
- Caterina Giannini (ORCID: https://orcid.org/0000-0003-2757-6782)
- Andrés Cervio (ORCID: https://orcid.org/0000-0001-7617-1605)
- Ho‐Keung Ng (ORCID: https://orcid.org/0000-0002-2614-2213)
- Sam R. Emerson (ORCID: https://orcid.org/0000-0001-7439-0871)
- Mohsen Javadpour (ORCID: https://orcid.org/0000-0001-9836-1741)
- Chaya Brodie
- Christina Jackson (ORCID: https://orcid.org/0000-0003-3831-2387)
- Antonio Santacroce (ORCID: https://orcid.org/0000-0003-4242-4197)
- Franz Ricklefs (ORCID: https://orcid.org/0000-0002-1321-6930)
- Aaron A Cohen-Gadol
- Felix Ehret (ORCID: https://orcid.org/0000-0001-6177-1755)
- Abdurrahman I. Islim (ORCID: https://orcid.org/0000-0001-9621-043X)
- Qingxia Wei (ORCID: https://orcid.org/0000-0002-7723-6180)
- Sylvia C. Kurz (ORCID: https://orcid.org/0000-0002-5247-5636)
- Brij Karmur (ORCID: https://orcid.org/0000-0002-4224-173X)
- Tathiane M. Malta (ORCID: https://orcid.org/0000-0003-1129-5791)
- Lola B. Chambless (ORCID: https://orcid.org/0000-0001-5864-5387)
- Christopher P. Millward (ORCID: https://orcid.org/0000-0001-7727-1157)
- Matija Snuderl (ORCID: https://orcid.org/0000-0003-0752-0917)
- Houtan Noushmehr (ORCID: https://orcid.org/0000-0003-4051-8114)
- Konstantinos Fountas (ORCID: https://orcid.org/0000-0002-3415-3799)
- Eelke M. Bos (ORCID: https://orcid.org/0000-0003-3647-6740)
- Christine Jungk (ORCID: https://orcid.org/0009-0004-7911-0268)
- Susan C Short (ORCID: https://orcid.org/0000-0003-4423-7256)
- Gabriel Zada (ORCID: https://orcid.org/0000-0001-5821-902X)
- Omar Pathmanaban (ORCID: https://orcid.org/0000-0002-5083-9416)
- Andrew Edward Sloan (ORCID: https://orcid.org/0000-0001-9607-5063)
- Sheila Mansouri (ORCID: https://orcid.org/0000-0002-7255-207X)
- Nicholas Butowski (ORCID: https://orcid.org/0000-0001-5162-2406)
- Ghazaleh Tabatabai (ORCID: https://orcid.org/0000-0002-3542-8782)
- Peter Paßlack
- Nils Ole Schimdt
- Bruno Carvalho (ORCID: https://orcid.org/0000-0002-3972-7544)
- Michael McDermott (ORCID: https://orcid.org/0000-0002-7635-5268)
- Ian Lee (ORCID: https://orcid.org/0000-0001-6057-7176)
- Andrew Gao (ORCID: https://orcid.org/0000-0002-2204-3277)
- Rajarshi Mukherjee (ORCID: https://orcid.org/0000-0002-8707-6248)
- Andrea Saladino (ORCID: https://orcid.org/0000-0002-6439-6556)
- Ian F. Dunn (ORCID: https://orcid.org/0000-0003-0275-6736)
- Alexander Landry (ORCID: https://orcid.org/0000-0002-7250-8466)
- Alper Dincer (ORCID: https://orcid.org/0000-0002-8078-3214)
- Warren R. Selman
- Emilie LeRhun
- Robert Smee
- J. Chen
- James P. Snyder
- Michael A. Vogelbaum (ORCID: https://orcid.org/0000-0002-9833-2374)
- Kenneth Aldape
- Jörg‐Christian Tonn
- Malak AlThgafi
- Tzannis Alkividias
- Vitowanu Julius
- Miguel Millareschavez
- Duong Trung Kien
Institutions
- University Health Network (CA)
- Mayo Clinic (US)
- University of British Columbia (CA)
- German Cancer Research Center (DE)
- University of Toronto (CA)
- Keck Hospital of USC (US)
- WinnMed (US)
- Princess Margaret Cancer Centre (CA)
- Humboldt-Universität zu Berlin (DE)
- Piedmont Cancer Institute (US)
- German Cancer Society (DE)
- German Centre for Cardiovascular Research (DE)
- Central Brain Tumor Registry of the United States (US)
- Bernstein Center for Computational Neuroscience Tübingen (DE)
- National Cancer Institute (US)
- Hertie Institute for Clinical Brain Research (DE)
- Mayo Clinic in Florida (US)
- Center for Cancer Research (US)
- Neurological Surgery (US)
- Division of Cancer Epidemiology and Genetics
- Deutsches Konsortium für Translationale Krebsforschung (DE)
- Charité - Universitätsmedizin Berlin (DE)
- University of Tübingen (DE)
- Penn State Milton S. Hershey Medical Center (US)
- Vanderbilt University Medical Center (US)
Publication Details
- Journal
- Neuro-Oncology
- Published
- 2025-11-15
- DOI
- https://doi.org/10.1093/neuonc/noaf237
- Primary Topic
- Meningioma and schwannoma management
- Type
- article
- Field-Weighted Citation Impact
- 0.00