A framework for using DNA methylation-based modelling for the clinical management of cranial meningioma

We identify methylation-defined risk groups of meningioma for which additional benefit is gained from adjuvant RT, leading to a clinical decision-making framework for straightforward integration of molecular models into clinical practice.

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Publication Details

Journal
Neuro-Oncology
Published
2025-11-15
DOI
https://doi.org/10.1093/neuonc/noaf237
Primary Topic
Meningioma and schwannoma management
Type
article
Field-Weighted Citation Impact
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article

A framework for using DNA methylation-based modelling for the clinical management of cranial meningioma

Bianca Pollo, Mirjam Renovanz, Sybren L. N. Maas, Luke Hnenny et al.
Neuro-Oncology
Meningioma and schwannoma management
article

A framework for using DNA methylation-based modelling for the clinical management of cranial meningioma

Bianca Pollo, Mirjam Renovanz, Sybren L. N. Maas, Luke Hnenny, Aditya Raghunathan, Jennifer Moliterno, Jeff Liu, Farshad Nassiri, Bryan J. Neth, Tiit Illimar Mathiesen, David Ronan Raleigh, Paul C. Boutros, Craig Horbinski, Maximilian Deng, Tobias Greve, Aaron Cohen‐Gadol, Vikas Patil, Quinn T. Ostrom, Maciej M. Mrugała, Priscilla Kaliopi Brastianos, Viktor Zherebitskiy, James A. Balogun, Jana Ivanidze, Michael Weller, Evanthia Galanis, Katrin Lamszus, Roland Goldbrunner, Mark W. Youngblood, Richard G. Everson, Patrick Yung Wen, Christel C. Herold‐Mende, Christian la Fougère, Tobias Walbert, Francesco DiMeco, Carolina Benjamin, Deva S. Jeyaretna, Christian Mawrin, Andrew Morokoff, Olivia Singh, Laura Fariselli, Felix Behling, Chloe Gui, Joshua D. Palmer, Philipp Karschnia, Yazmín Odia, Minesh P. Mehta, Rafael Martínez-Pérez, David Capper, Christian Schichor, Katharine J. Drummond, Evan Calabrese, Jens Schittenhelm, Marco Timmer, Leeor Yefet, Michelle M. Felicella, Marcos Soares Tatagiba, Stephen Yip, C. Oliver Hanemann, Helen Alice Shih, Daniele Scartoni, Wenya Linda Bi, Norbert Galldiks, Clinton P. Turner, Kyle M. Walsh, Daniel H. Lachance, Nico Teske, Derek S. Tsang, Jill S. Barnholtz‐Sloan, Alireza Mansouri, Serge Makarenko, Andreas von Deimling, Arie Perry, Christina Arvaniti, Andrew Ajisebutu, Erik P. Sulman, Justin Z. Wang, Yasin Mamatjan, Karolyn Au, Timothy J. Kaufmann, Michael D. Jenkinson, Ana Valéria Castro, William Muirhead, Kenneth Aldape, Cristina Matesanz López, Gerhard Jungwirth, Felix Sahm, Manfred Westphal, Michael E. Ivan, Raymond Y. Huang, Yosef Ellenbogen, Dante Amelio, Thomas Santarius, Daniel M. Fountain, Marta Couce, Caterina Giannini, Andrés Cervio, Ho‐Keung Ng, Sam R. Emerson, Mohsen Javadpour, Chaya Brodie, Christina Jackson, Antonio Santacroce, Franz Ricklefs, Aaron A Cohen-Gadol, Felix Ehret, Abdurrahman I. Islim, Qingxia Wei, Sylvia C. Kurz, Brij Karmur, Tathiane M. Malta, Lola B. Chambless, Christopher P. Millward, Matija Snuderl, Houtan Noushmehr, Konstantinos Fountas, Eelke M. Bos, Christine Jungk, Susan C Short, Gabriel Zada, Omar Pathmanaban, Andrew Edward Sloan, Sheila Mansouri, Nicholas Butowski, Ghazaleh Tabatabai, Peter Paßlack, Nils Ole Schimdt, Bruno Carvalho, Michael McDermott, Ian Lee, Andrew Gao, Rajarshi Mukherjee, Andrea Saladino, Ian F. Dunn, Alexander Landry, Alper Dincer, Warren R. Selman, Emilie LeRhun, Robert Smee, J. Chen, James P. Snyder, Michael A. Vogelbaum, Kenneth Aldape, Jörg‐Christian Tonn, Malak AlThgafi, Tzannis Alkividias, Vitowanu Julius, Miguel Millareschavez, Duong Trung Kien
article en

Abstract

We identify methylation-defined risk groups of meningioma for which additional benefit is gained from adjuvant RT, leading to a clinical decision-making framework for straightforward integration of molecular models into clinical practice.

Neuro-OncologyVol. 28(2)
University Health Network (CA), Mayo Clinic (US), University of British Columbia (CA), German Cancer Research Center (DE), University of Toronto (CA), Keck Hospital of USC (US), WinnMed (US), Princess Margaret Cancer Centre (CA), Humboldt-Universität zu Berlin (DE), Piedmont Cancer Institute (US), German Cancer Society (DE), German Centre for Cardiovascular Research (DE), Central Brain Tumor Registry of the United States (US), Bernstein Center for Computational Neuroscience Tübingen (DE), National Cancer Institute (US), Hertie Institute for Clinical Brain Research (DE), Mayo Clinic in Florida (US), Center for Cancer Research (US), Neurological Surgery (US), Division of Cancer Epidemiology and Genetics, Deutsches Konsortium für Translationale Krebsforschung (DE), Charité - Universitätsmedizin Berlin (DE), University of Tübingen (DE), Penn State Milton S. Hershey Medical Center (US), Vanderbilt University Medical Center (US)
Openalex Percentile: Top 54%
Meningioma and schwannoma management
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