Predictive value of interferon-gamma release assays and tuberculin skin test for latent tuberculosis infection: A systematic review and meta-analysis of head-to-head comparative tests
IGRA appears to have superior predictive value for TB progression compared to TST. Additionally, incorporating TST alongside IGRA does not seem to significantly enhance predictive accuracy. IGRA effectively reduces the number of individuals requiring treatment while seemingly not missing those at risk of progression.
Authors
- Shunli Cai
- Guangtao Xia (ORCID: https://orcid.org/0000-0001-5975-3785)
- Jian‐Qing He (ORCID: https://orcid.org/0000-0002-0966-1302)
- Hongbo Chen (ORCID: https://orcid.org/0000-0003-4341-5698)
- Guozhong Zhou (ORCID: https://orcid.org/0009-0001-9112-6631)
- Qinghua Gao (ORCID: https://orcid.org/0000-0003-4746-7700)
- Xin Guo (ORCID: https://orcid.org/0000-0003-4436-8387)
- Yating Yi (ORCID: https://orcid.org/0000-0003-2283-1959)
- Qiaoli Zhang (ORCID: https://orcid.org/0009-0001-7975-9903)
- Liping Chen (ORCID: https://orcid.org/0000-0002-8110-5378)
- Yan Dong (ORCID: https://orcid.org/0000-0002-4018-3839)
- Yun Huang (ORCID: https://orcid.org/0000-0003-4720-0168)
- Xuesong Chen (ORCID: https://orcid.org/0009-0009-6011-6738)
Institutions
- Kunming University of Science and Technology (CN)
- Kunming Medical University (CN)
- First People's Hospital of Yunnan Province (CN)
- First Affiliated Hospital of Kunming Medical University (CN)
Publication Details
- Journal
- Journal of Microbiology Immunology and Infection
- Published
- 2025-11-01
- DOI
- https://doi.org/10.1016/j.jmii.2025.11.003
- Primary Topic
- Tuberculosis Research and Epidemiology
- Type
- article
- Field-Weighted Citation Impact
- 0.00