An extended cost-effectiveness analysis of decentralised TB diagnostic testing with Molbio Truenat MTB/RIF versus hub-and-spoke GeneXpert MTB/RIF in Mozambique and Tanzania
The intervention reduced patient costs and improved outcomes across SES groups. Decentralised TB testing with the Molbio Truenat platform is both cost-saving and more effective and cost-effective compared with a hub-and-spoke model in Mozambique and Tanzania.
Authors
- Manuela De Allegri (ORCID: https://orcid.org/0000-0002-8677-1337)
- Vinzeigh Leukes (ORCID: https://orcid.org/0000-0002-9864-874X)
- Claudia Maria Denkinger (ORCID: https://orcid.org/0000-0002-7216-7067)
- Leyla Larsson (ORCID: https://orcid.org/0000-0003-4869-4630)
- Saima Bashir (ORCID: https://orcid.org/0000-0002-4558-9432)
- Anange Lwilla (ORCID: https://orcid.org/0000-0002-8011-6948)
- Nancy K. Young
- Jerry Hella (ORCID: https://orcid.org/0000-0003-2392-8592)
- Morten Rühwald (ORCID: https://orcid.org/0000-0002-1597-441X)
- Lelisa Fekadu Assebe (ORCID: https://orcid.org/0000-0002-7857-3349)
- David W. Dowdy (ORCID: https://orcid.org/0000-0003-0481-7475)
- Akash Malhotra (ORCID: https://orcid.org/0000-0002-9298-0936)
- Mikaela Watson (ORCID: https://orcid.org/0000-0001-7941-1643)
- Adam Penn‐Nicholson (ORCID: https://orcid.org/0000-0002-1883-0059)
- António Machiana
- Délio Elísio
Institutions
- Ifakara Health Institute (TZ)
- FIND (CH)
- Johns Hopkins University (US)
- University of Washington (US)
- Heidelberg University (DE)
- Government of Ethiopia (ET)
- University Hospital Heidelberg (DE)
- University of Manchester (GB)
- Biomedical Research and Training Institute (ZW)
- German Center for Infection Research (DE)
- Manhiça Health Research Centre (MZ)
- Instituto Nacional de Saúde (MZ)
- National Institute for Medical Research (TZ)
- University of Bergen (NO)
- Ludwig-Maximilians-Universität München (DE)
Publication Details
- Journal
- BMJ Global Health
- Published
- 2025-11-01
- DOI
- https://doi.org/10.1136/bmjgh-2025-020117
- Primary Topic
- Tuberculosis Research and Epidemiology
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- European Commission
- National Institute of Allergy and Infectious Diseases
- European and Developing Countries Clinical Trials Partnership