Risk factors for severe knee osteoarthritis and efficacy of diacerein in obese vietnamese patients: A randomized, single-blind, noncontrolled clinical trial
Increased waist circumference, plasma TG, and TG/high density of lipoprotein cholesterol ratio raise the risk of severe knee OA. Diacerein treatment improves symptoms and joint function in patients with knee OA accompanied by obesity, with the 100-mg/day dose showing earlier and more effective improvement than the 50-mg/day dose.
Authors
- Hong Nhung Nguyen (ORCID: https://orcid.org/0000-0002-5024-7840)
- Minh Hoàng Phan
- Hoang Khanh Pham
- Minh Phuong Vo
- Huynh Trang Vo
- Thuan Huynh (ORCID: https://orcid.org/0009-0002-6437-918X)
- Minh Chau Tran (ORCID: https://orcid.org/0000-0002-0653-1692)
- Van Phu La
Institutions
- Can Tho University (VN)
- HCMC Hospital of Dermato Venereology (VN)
- Can Tho University of Medicine and Pharmacy
Publication Details
- Journal
- Medicine
- Published
- 2025-10-31
- DOI
- https://doi.org/10.1097/md.0000000000045506
- Primary Topic
- Osteoarthritis Treatment and Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 0.00