Cronkhite-Canada syndrome presenting with chronic diarrhea: A case report

In this case, diffuse, variably sized, densely distributed, congestive polypoid changes were seen throughout the stomach, colon, rectum, and the terminal ileum. The lesions were more pronounced in the distal region of the gastric body than in the proximal region. Histopathology was suggestive of hamartomatous polyps with infiltration by eosinophils, lymphocytes, and plasma cells. Hormonal therapy has shown significant efficacy in treating this disease. Timely therapeutic intervention combined with systematic surveillance may mitigate the potential for malignant transformation and disease-related complications.

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Publication Details

Journal
Medicine
Published
2025-10-31
DOI
https://doi.org/10.1097/md.0000000000045458
Primary Topic
Genetic factors in colorectal cancer
Type
article
Field-Weighted Citation Impact
0.00
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article

Cronkhite-Canada syndrome presenting with chronic diarrhea: A case report

Junjun Wu, Yufang Wang, S Wu
Medicine
Genetic factors in colorectal cancer
article

Cronkhite-Canada syndrome presenting with chronic diarrhea: A case report

Junjun Wu, Yufang Wang, S Wu
article en

Abstract

In this case, diffuse, variably sized, densely distributed, congestive polypoid changes were seen throughout the stomach, colon, rectum, and the terminal ileum. The lesions were more pronounced in the distal region of the gastric body than in the proximal region. Histopathology was suggestive of hamartomatous polyps with infiltration by eosinophils, lymphocytes, and plasma cells. Hormonal therapy has shown significant efficacy in treating this disease. Timely therapeutic intervention combined with systematic surveillance may mitigate the potential for malignant transformation and disease-related complications.

MedicineVol. 104(44)
Zhejiang Chinese Medical University (CN), Third People's Hospital of Hangzhou (CN)
Openalex Percentile: Top 52%
Genetic factors in colorectal cancer
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