Thrombotic Thrombocytopenic Purpura During Anti-Tuberculosis Therapy: A Case Report and Literature Review
This case highlights TTP as a rare but serious complication of anti-TB therapy. Clinical vigilance is essential, including platelet monitoring during initial treatment and a low threshold for ADAMTS13 testing in cases of unexplained thrombocytopenia. Future multicenter studies are needed to investigate immune mechanisms and assess therapies such as rituximab, with the aim of optimizing management strategies for rare adverse drug events and improving patient outcomes.
Authors
- Zhixiong Fang (ORCID: https://orcid.org/0000-0002-9463-6207)
- Sha Lin (ORCID: https://orcid.org/0000-0001-9582-3306)
- Haiyan Xue (ORCID: https://orcid.org/0000-0002-8600-9270)
- Liping He (ORCID: https://orcid.org/0000-0003-2818-393X)
- Haiming Zhang (ORCID: https://orcid.org/0000-0001-5986-5314)
- Wei Tang (ORCID: https://orcid.org/0000-0002-1621-0980)
Institutions
- Hunan University of Science and Technology (CN)
- Xiangyang Central Hospital (CN)
- Xiangtan University (CN)
Publication Details
- Journal
- Infection and Drug Resistance
- Published
- 2025-11-01
- DOI
- https://doi.org/10.2147/idr.s544621
- Citations
- 1
- Primary Topic
- Complement system in diseases
- Type
- article
- Field-Weighted Citation Impact
- 0.80