First Report of Treatment-Emergent Resistance to Cefepime-Zidebactam in <i>Pseudomonas aeruginosa</i>
We describe the first case of cefepime-zidebactam treatment-emergent resistance associated with clinical failure in a patient with Pseudomonas aeruginosa pneumonia. During treatment, cefepime-zidebactam minimum inhibitory concentrations increased from 8/8 to 32/32 mg/L. Whole-genome sequence analysis showed new mutations in the MexAB-OprM efflux operon that were associated with cross-resistance to ceftazidime-avibactam and imipenem-relebactam.
Authors
- Virginia Pierce (ORCID: https://orcid.org/0000-0002-3723-1326)
- Ellen G Kline (ORCID: https://orcid.org/0009-0006-7167-6368)
- Kevin M Squires (ORCID: https://orcid.org/0009-0007-7818-905X)
- Jason M. Pogue (ORCID: https://orcid.org/0000-0003-4780-6215)
- Ryan K. Shields (ORCID: https://orcid.org/0000-0001-9794-5665)
- Samuel L Aitken (ORCID: https://orcid.org/0000-0002-8659-4238)
- Ava J Dorazio
Institutions
- University of Pittsburgh (US)
- University of Michigan (US)
- Michigan Medicine (US)
- University of Pittsburgh Medical Center (US)
Publication Details
- Journal
- Clinical Infectious Diseases
- Published
- 2025-11-15
- DOI
- https://doi.org/10.1093/cid/ciaf638
- Citations
- 3
- Primary Topic
- Antibiotic Resistance in Bacteria
- Type
- article
- Field-Weighted Citation Impact
- 1.77