Trauma-induced alterations in bone marrow exosome microRNA profiles
Chronic critical illness following severe trauma alters bone marrow exosome miRNA profiles, modulating gene regulatory mechanisms involved in injury response, inflammation, and recovery. These patterns suggest that chronic stress exacerbates trauma-induced bone marrow dysfunction by disrupting hematopoietic stem/progenitor growth maintenance, lineage specification, and tissue repair signaling.
Authors
- Athina L. Yoham (ORCID: https://orcid.org/0009-0006-5460-4354)
- Alicia M. Mohr (ORCID: https://orcid.org/0000-0003-1732-1313)
- Robert Maile (ORCID: https://orcid.org/0000-0002-9126-4188)
- Kolenkode B. Kannan
- Philip A. Efron (ORCID: https://orcid.org/0000-0002-3931-650X)
- Letitia Bible (ORCID: https://orcid.org/0000-0002-5417-4028)
- C. A. Wheeler (ORCID: https://orcid.org/0009-0009-7537-6399)
- Miguel Hernández-Ríos (ORCID: https://orcid.org/0009-0004-2181-8773)
- Christine Rodhouse (ORCID: https://orcid.org/0009-0009-4202-6528)
- Agneta Peethala
Institutions
- RELX Group (Netherlands) (NL)
- University of Florida (US)
- Florida College (US)
Publication Details
- Journal
- The Journal of Trauma: Injury, Infection, and Critical Care
- Published
- 2025-11-12
- DOI
- https://doi.org/10.1097/ta.0000000000004831
- Primary Topic
- Extracellular vesicles in disease
- Type
- article
- Field-Weighted Citation Impact
- 0.00