Study on the Effects of Doxycycline Treatment on Endometrial Microbiota and Pregnancy Outcomes in Chronic Endometritis

Despite histological resolution following doxycycline therapy, CE patients exhibited persistent dysbiosis characterized by decreased Lactobacillus and increased opportunistic taxa, which may impair endometrial receptivity and pregnancy outcomes. These findings suggest that antibiotic therapy alone may not fully restore microbial balance in CE, warranting further investigation into microbiota-targeted interventions to improve reproductive success.