Impact of DNA-stored mutations on virological response in virologically suppressed PWH in the switch to modern regimens
Our findings evidence the role of archived resistance in predicting VR after switch therapy in suppressed PWH. Thus, proviral GRT could be a useful tool to optimise strategies for switching treatment, especially if paired with information on previous historical resistance and the duration under suppression.
Authors
- Adrian Shallvari
- Ilaria Vicenti (ORCID: https://orcid.org/0000-0002-4306-2960)
- Leonardo Duca (ORCID: https://orcid.org/0009-0008-2970-2037)
- Stefano Rusconi (ORCID: https://orcid.org/0000-0002-0375-9990)
- Antonia Bezenchek
- Francesca Lombardi (ORCID: https://orcid.org/0000-0001-5757-8346)
- William Gennari (ORCID: https://orcid.org/0000-0002-8823-8173)
- Laura Pezzati (ORCID: https://orcid.org/0000-0002-7306-342X)
- Valeria Micheli (ORCID: https://orcid.org/0000-0001-5629-3875)
- Elio Gentilini Cacciola (ORCID: https://orcid.org/0000-0001-5479-9055)
- Francesco Bassani (ORCID: https://orcid.org/0009-0001-7002-7044)
- Federica Carli (ORCID: https://orcid.org/0000-0002-4055-234X)
- Aude Christelle Ka’e (ORCID: https://orcid.org/0000-0002-2381-4299)
- Anita Pupo
- Francesco Saladini (ORCID: https://orcid.org/0000-0002-9934-377X)
- O El Khalili (ORCID: https://orcid.org/0000-0003-1345-6800)
- Chiara Muscatiello
- Maria Mercedes Santoro
- Alessandro Cozzi-Lepri
Institutions
- University of Siena (IT)
- Università Cattolica del Sacro Cuore (IT)
- University of Foggia (IT)
- University of Rome Tor Vergata (IT)
- University of Modena and Reggio Emilia (IT)
- University of Milan (IT)
- Agostino Gemelli University Polyclinic (IT)
- Centre International De Reference Chantal Biya (CM)
- Informa (Italy) (IT)
- Ospedale di Parma (IT)
- ASST Fatebenefratelli Sacco (IT)
- Sapienza University of Rome (IT)
Publication Details
- Journal
- International Journal of Antimicrobial Agents
- Published
- 2025-11-20
- DOI
- https://doi.org/10.1016/j.ijantimicag.2025.107670
- Primary Topic
- Virus-based gene therapy research
- Type
- article
- Field-Weighted Citation Impact
- 0.00