Influence of Topical Fluorescein on Scheimpflug-Based Corneal Densitometry and Potential Applications
Topical fluorescein induces time-dependent changes in anterior corneal densitometry, with measurements returning close to baseline by 20-minute postinstillation in healthy eyes. In patients with DED, fluorescein may locally enhance densitometry of epithelial defects and could offer a novel, objective method for assessing corneal surface integrity. Further studies are needed to validate its clinical utility.
Authors
- Perseverence Savieri (ORCID: https://orcid.org/0000-0001-7853-0421)
- Silke Oellerich (ORCID: https://orcid.org/0000-0002-5703-5971)
- Sorcha Ní Dhubhghaill (ORCID: https://orcid.org/0000-0002-1115-7834)
- Nima Sadeghi (ORCID: https://orcid.org/0009-0001-5751-8463)
Institutions
- Vrije Universiteit Brussel (BE)
- Universitair Ziekenhuis Brussel (BE)
Publication Details
- Journal
- Cornea
- Published
- 2025-10-28
- DOI
- https://doi.org/10.1097/ico.0000000000004025
- Primary Topic
- Corneal surgery and disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00