Drug-induced liver injury: a real-world pharmacovigilance study using the FDA Adverse Event Reporting System database (2004–2024)
Our study summarized a reported culprit-drug list of DILI by comprehensively reviewing the liver injury-related reports in the FAERS database, and highlighted the prominent position of antineoplastic agents in reporting frequency, risk signal strength ranking, number of positive signal drugs, and high-risk drug distribution, suggesting that we may need to pay more attention to the liver injury risk of antineoplastic agents in clinical practice.
Authors
- Duan Wang (ORCID: https://orcid.org/0000-0001-5487-4414)
- Qian Du (ORCID: https://orcid.org/0000-0001-8354-7500)
- Guili Huang
- Yalan Wang (ORCID: https://orcid.org/0009-0001-4363-7234)
- Rui Zhang (ORCID: https://orcid.org/0009-0000-9961-1108)
- Songqing Liu (ORCID: https://orcid.org/0000-0002-9269-3961)
- Dongxuan Li (ORCID: https://orcid.org/0000-0001-5215-5942)
- Qinglong Liu (ORCID: https://orcid.org/0009-0000-2289-8980)
Institutions
- Army Medical University (CN)
- Third People 's Hospital of Chongqing (CN)
- Xinqiao Hospital (CN)
- The Affiliated Yongchuan Hospital of Chongqing Medical University (CN)
- Chongqing Medical University (CN)
Publication Details
- Journal
- Annals of Hepatology
- Published
- 2025-11-20
- DOI
- https://doi.org/10.1016/j.aohep.2025.102156
- Primary Topic
- Drug-Induced Hepatotoxicity and Protection
- Type
- article
- Field-Weighted Citation Impact
- 0.00