Machine learning identifies a distinct microbiota signature in immune checkpoint inhibitor colitis compared with inflammatory bowel disease
A unique microbiota signature characterizes ICIs-colitis compared to IBD and HCs. These findings underscore the potential of microbiota profiling and machine learning to aid in diagnosing and managing ICIs-colitis. Future studies should validate these findings in larger, multicenter cohorts, and explore therapeutic implications.
Authors
- Barbara Simionati (ORCID: https://orcid.org/0000-0002-0522-0737)
- Luisa Bertin (ORCID: https://orcid.org/0009-0001-9816-4171)
- Patrizia Burra (ORCID: https://orcid.org/0000-0002-8791-191X)
- Angelo Paolo Dei Tos (ORCID: https://orcid.org/0000-0002-1228-8940)
- Eleonora Sattin (ORCID: https://orcid.org/0000-0002-6785-9624)
- Fabiana Zingone (ORCID: https://orcid.org/0000-0003-1133-1502)
- Andrea Buda (ORCID: https://orcid.org/0000-0002-3099-8612)
- S. Frega (ORCID: https://orcid.org/0000-0002-2998-5072)
- Sonia Facchin (ORCID: https://orcid.org/0000-0002-6774-590X)
- Marianna De Ruvo
- Brigida Barberio (ORCID: https://orcid.org/0000-0002-3164-8243)
- Laura Bonanno (ORCID: https://orcid.org/0000-0001-5218-4970)
- Alessandro Dal Maso (ORCID: https://orcid.org/0000-0003-3743-717X)
- Erica Bonazzi
- Edoardo Vincenzo Savarino (ORCID: https://orcid.org/0000-0002-3187-2894)
- Ilaria Patuzzi (ORCID: https://orcid.org/0000-0002-4793-106X)
- Giulia Pasello (ORCID: https://orcid.org/0000-0002-8741-6038)
- Caterina De Barba
Institutions
- University of Padua (IT)
- Biomolecular Research Genomics (Italy) (IT)
- Istituto Oncologico Veneto (IT)
- Regione del Veneto (IT)
- Istituti di Ricovero e Cura a Carattere Scientifico (IT)
- Hospital of Prato (IT)
Publication Details
- Journal
- The Oncologist
- Published
- 2025-11-15
- DOI
- https://doi.org/10.1093/oncolo/oyaf376
- Primary Topic
- Inflammatory Bowel Disease
- Type
- article
- Field-Weighted Citation Impact
- 0.00