Nephrotoxicity of conventional chemotherapeutics: part 1—platinum compounds and antimetabolite agents
Anticancer therapies have significantly improved survival rates in patients with cancer; however, despite prophylactic measures, many conventional chemotherapeutic agents cause acute and chronic kidney injury. This review provides a comprehensive analysis of the incidence, characteristics, and management of platinum-based and anti-metabolite chemotherapeutic agent-associated nephrotoxicity based on the existing literature. Understanding the profiles of these onconephrotoxic agents is essential for optimizing anticancer treatment while minimizing kidney complications.
Authors
- Adam Kelly
- Omar Mamlouk (ORCID: https://orcid.org/0000-0002-1242-2740)
- Kenar D. Jhaveri (ORCID: https://orcid.org/0000-0003-1578-0524)
- Kartik Kalra
- Tanazul T. Pariswala
- Sylvia S Eskander
- Sourabh Sharma (ORCID: https://orcid.org/0000-0002-9729-5129)
- Mark A. Perazella (ORCID: https://orcid.org/0000-0002-6994-2659)
- Shruti Gupta (ORCID: https://orcid.org/0000-0002-5747-2151)
- Marco A. Bonilla (ORCID: https://orcid.org/0000-0001-9087-9730)
- Mohamed Ibrahim
- Prakash Gudsoorkar (ORCID: https://orcid.org/0000-0001-9044-6054)
- Paul E. Hanna (ORCID: https://orcid.org/0000-0003-4976-9104)
- Mohamed Hassanein (ORCID: https://orcid.org/0000-0002-8247-5936)
- Anna-Eve Turcotte
- Munjal Patel (ORCID: https://orcid.org/0000-0001-6892-0899)
- Raad B. Chowdhury (ORCID: https://orcid.org/0000-0002-9347-6299)
- Carl Dernell
- Rimda Wanchoo
- Ishaan Zaveri
- Heather Troung
Institutions
- Brigham and Women's Hospital (US)
- Northeastern University (US)
- Geisinger Medical Center (US)
- The University of Texas MD Anderson Cancer Center (US)
- Harvard University (US)
- Vardhman Mahavir Medical College & Safdarjung Hospital (IN)
- Medical College of Wisconsin (US)
- Centre Hospitalier Universitaire de Sherbrooke (CA)
- Yale University (US)
- University of Illinois Chicago (US)
- University of Chicago (US)
- Universal Scientific Education and Research Network (IR)
- Donald & Barbara Zucker School of Medicine at Hofstra/Northwell (US)
- Dana-Farber Cancer Institute (US)
- Loxo Oncology at Lilly (United States) (US)
- Methodist Dallas Medical Center (US)
- Dana-Farber Brigham Cancer Center (US)
- Children's Specialized Hospital (US)
- Cooper Union (US)
- The University of Texas Health Science Center at Houston (US)
- University of Cincinnati Medical Center (US)
Publication Details
- Journal
- Nephrology Dialysis Transplantation
- Published
- 2025-11-15
- DOI
- https://doi.org/10.1093/ndt/gfaf251
- Primary Topic
- Chemotherapy-induced organ toxicity mitigation
- Type
- article
- Field-Weighted Citation Impact
- 0.00