Best therapeutic approach in metastatic hormone-sensitive prostate cancer based on disease volume: a systematic review and network meta-analysis
The results provide collective evidence for treatment selection based on disease volume and timing of metastasis with strongest survival benefits of triplets for high-volume/synchronous mHSPC patients and of ARPI doublets for low-volume disease.
Authors
- Massimo Di Maïo (ORCID: https://orcid.org/0000-0001-8906-3785)
- Fabrizio Di Costanzo
- Pasquale Rescigno (ORCID: https://orcid.org/0000-0002-4668-4765)
- Giovanni Dima (ORCID: https://orcid.org/0000-0002-1973-734X)
- Matteo Santoni (ORCID: https://orcid.org/0000-0001-7340-6173)
- Christoph Oing (ORCID: https://orcid.org/0000-0001-5578-3418)
- Alessio Signori (ORCID: https://orcid.org/0000-0001-6289-9144)
- Luca Galli (ORCID: https://orcid.org/0000-0001-6008-0266)
- Alberto Briganti (ORCID: https://orcid.org/0000-0002-2178-0494)
- Vincenza Conteduca (ORCID: https://orcid.org/0000-0002-6921-714X)
- Luigi Formisano (ORCID: https://orcid.org/0000-0001-7294-8595)
- Sara Elena Rebuzzi (ORCID: https://orcid.org/0000-0003-0546-6304)
- Carlo G. M. Messina (ORCID: https://orcid.org/0000-0002-7934-1419)
- Giuseppe Procopio (ORCID: https://orcid.org/0000-0002-2498-402X)
- Francesco Montorsi (ORCID: https://orcid.org/0000-0002-7267-4181)
- Brigida Anna Maiorano (ORCID: https://orcid.org/0000-0001-5423-3158)
- Giuseppe Fornarini (ORCID: https://orcid.org/0000-0003-4754-6572)
- Andrea Necchi (ORCID: https://orcid.org/0000-0002-3007-2756)
- Chiara Mercinelli (ORCID: https://orcid.org/0000-0003-1165-1776)
- Giuseppe Luigi Banna
- Ugo De Giorgi
Institutions
- University of Foggia (IT)
- University of Salento (IT)
- Vita-Salute San Raffaele University (IT)
- Newcastle upon Tyne Hospitals NHS Foundation Trust (GB)
- Ospedale San Paolo (IT)
- Azienda Ospedaliera Citta' della Salute e della Scienza di Torino (IT)
- Ospedale Santa Chiara (IT)
- Portsmouth Hospitals NHS Trust (GB)
- Ospedale San Paolo (IT)
- Ospedali Riuniti di Foggia (IT)
- Mylan (South Africa) (ZA)
- Department of Medical Sciences (BY)
- IRCCS Ospedale San Raffaele (IT)
- University of Palermo (AR)
- Tumori Foundation (US)
- Ospedale Policlinico San Martino (IT)
- Ospedale Vito Fazzi (IT)
- Istituti di Ricovero e Cura a Carattere Scientifico (IT)
- Fondazione IRCCS Istituto Nazionale dei Tumori (IT)
- Istituto di Ricovero e Cura a Carattere Scientifico San Raffaele (IT)
- Ospedale di Macerata
- University of Macerata (IT)
- University of Turin (IT)
- University of Portsmouth (GB)
- University of Naples Federico II (IT)
- University of Genoa (IT)
- Newcastle University (GB)
Publication Details
- Journal
- The Oncologist
- Published
- 2025-11-15
- DOI
- https://doi.org/10.1093/oncolo/oyaf386
- Primary Topic
- Prostate Cancer Treatment and Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00