Jolkinolide B Mitigates Cerebral Ischemia–Reperfusion Injury by Promoting Microglial <scp>M1</scp> / <scp>M2</scp> Polarization Through the <scp>JAK2</scp> / <scp>STAT3</scp> Signaling Pathway
The ability of JB to modulate microglial polarization through JAK2/STAT3 inhibition presents a promising pharmacological approach for cerebral ischemia-reperfusion injury management in stroke therapy.
Authors
- Jianxin Wang (ORCID: https://orcid.org/0000-0002-1687-2829)
- Yupeng Guo (ORCID: https://orcid.org/0009-0008-9457-6786)
- Min Liu (ORCID: https://orcid.org/0000-0001-9066-4318)
- Dongsheng Liu (ORCID: https://orcid.org/0000-0001-5571-1932)
- Xuebin Dong (ORCID: https://orcid.org/0000-0002-6907-0491)
- Shewei Guo (ORCID: https://orcid.org/0009-0005-7333-0654)
Institutions
- First Affiliated Hospital of Zhengzhou University (CN)
- Aviation General Hospital (CN)
Publication Details
- Journal
- CNS Neuroscience & Therapeutics
- Published
- 2025-11-01
- DOI
- https://doi.org/10.1111/cns.70653
- Citations
- 2
- Primary Topic
- Neuroinflammation and Neurodegeneration Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 1.68