PGK1 Persulfidation Promotes the Proliferation and Metastasis of Breast Cancer
This study revealed a novel mechanism involved in the upregulation of endogenous H<sub>2</sub>S in breast cancer. Endogenous H<sub>2</sub>S regulates glycolysis of breast cancer cells by mediating PGK1 persulfidation modification at Cys108 and Cys316, thereby promoting tumor proliferation and metastasis. This study offers a potential therapeutic strategy through targeting the upregulated endogenous H<sub>2</sub>S and persulfidation of PGK1. <i>Antioxid. Redox Signal.</i> 44, 164-181.
Authors
- Chenghua Luo (ORCID: https://orcid.org/0000-0003-2453-3429)
- Y. Wang (ORCID: https://orcid.org/0000-0002-4781-5915)
- Kaige Yang
- Daiwen Chen (ORCID: https://orcid.org/0000-0002-8351-7421)
- Wei-Hua Liang
- Jianming Hu (ORCID: https://orcid.org/0000-0001-5821-3517)
- Yuxiang Xu (ORCID: https://orcid.org/0009-0009-3071-426X)
- Mengmeng Zhao (ORCID: https://orcid.org/0000-0002-2329-4342)
Institutions
- Shihezi University (CN)
- Capital Medical University (CN)
Publication Details
- Journal
- Antioxidants and Redox Signaling
- Published
- 2025-11-13
- DOI
- https://doi.org/10.1177/15230864251394334
- Primary Topic
- Sulfur Compounds in Biology
- Type
- article
- Field-Weighted Citation Impact
- 0.00