Femtolitre Volume cryoEM Sample Preparation Using a Force‐Sensitive Microfluidic Cantilever (Adv. Mater. Technol. 22/2025)
Force-Sensitive Microfluidic Cantilevers This image presents a novel method for cryoEM sample preparation using a force-sensitive microfluidic AFM cantilever. It enables femtolitre-scale extraction of subcellular material from individual cells and precise dispensing onto cryoEM grids. The technique allows high-resolution imaging of biological structures in native context, addressing limitations of conventional methods and offering new possibilities for cellular ultrastructure studies. More information can be found in the Research Article by Arjen J. Jakobi, Murali Krishna Ghatkesar, Andreas Engel, and co-workers (10.1002/admt.202501333).
Authors
- Murali Krishna Ghatkesar (ORCID: https://orcid.org/0000-0001-8423-3159)
- Eleonoor Verlinden
- Joachim W. Pronk
- Vijayendra Shastri (ORCID: https://orcid.org/0000-0002-5270-5112)
- P. L. T. M. Frederix (ORCID: https://orcid.org/0000-0002-0526-5257)
- Daniela Gonzalez (ORCID: https://orcid.org/0000-0002-8342-4639)
- Paul Laeven
- U. Staufer (ORCID: https://orcid.org/0000-0002-3519-6467)
- Andreas Engel (ORCID: https://orcid.org/0000-0002-0118-8733)
- Edin Sarajlic (ORCID: https://orcid.org/0000-0002-6184-3234)
- Arjen J. Jakobi (ORCID: https://orcid.org/0000-0002-7761-2027)
- Wiel H. Evers (ORCID: https://orcid.org/0000-0002-3413-5128)
Institutions
- Maastricht University (NL)
- Psychiatry Baselland (CH)
- ASML (Netherlands) (NL)
- Delft University of Technology (NL)
Publication Details
- Journal
- Advanced Materials Technologies
- Published
- 2025-11-01
- DOI
- https://doi.org/10.1002/admt.70242
- Primary Topic
- Force Microscopy Techniques and Applications
- Type
- article
- Field-Weighted Citation Impact
- 0.00