Caffeine Protects Newborn Rat Lungs Against the Effects of Hyperoxia and Intra‐Amniotic Enterotoxin
In a BPD-like model induced by prenatal (i.a. ETX) or postnatal (HYP) factors, caffeine administration preserved lung function and structure and prevented pulmonary hypertension. These findings confirm that caffeine (the drug most commonly prescribed in neonatal care units) may provide an effective strategy for BPD prevention when prenatal or postnatal factors are involved.
Authors
- Gino Villetti
- Carmen Rey‐Santano (ORCID: https://orcid.org/0000-0002-3855-3327)
- Chiara Catozzi
- Francesca Ricci (ORCID: https://orcid.org/0000-0001-5566-9519)
- Victoria Mielgo (ORCID: https://orcid.org/0000-0001-6386-6133)
- Miguel Angel Gomez‐Solaetxe (ORCID: https://orcid.org/0000-0003-1509-046X)
Institutions
- University of the Basque Country (ES)
- BioCruces Health research Institute (ES)
- Chiesi Foundation (IT)
Publication Details
- Journal
- Pediatric Pulmonology
- Published
- 2025-11-01
- DOI
- https://doi.org/10.1002/ppul.71395
- Primary Topic
- Adenosine and Purinergic Signaling
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Chiesi Farmaceutici
- Instituto de Salud Carlos III
- European Regional Development Fund