Evaluation of Phenotypic and Genotypic Susceptibility Testing Methods for Newer β-lactam/β-lactamase Inhibitor Combinations in Multidrug Resistant <i>Pseudomonas aeruginosa</i>
The Sensititre panel met standard acceptance criteria while the Phoenix panel had low CA for all tested BL/BLIs compared to BMD. Acquired β-lactamases were a rare cause of BL/BLI resistance. Further understanding of resistance mechanisms is required before phenotypic BL/BLI resistance can be reliably predicted from genotype, especially in settings where prevalence of acquired β-lactamases is low.
Authors
- Patryk Aftanas (ORCID: https://orcid.org/0000-0003-0437-5929)
- Robert Andrew Kozak (ORCID: https://orcid.org/0000-0002-6159-9972)
- Finlay Maguire (ORCID: https://orcid.org/0000-0002-1203-9514)
- Xena X. Li (ORCID: https://orcid.org/0000-0003-1510-6310)
- Christie Vermeiren
- Clayton W. Hall (ORCID: https://orcid.org/0000-0002-4623-3534)
- Kevin Katz (ORCID: https://orcid.org/0000-0001-5654-2683)
- Nicholas Waglechner (ORCID: https://orcid.org/0000-0003-1758-1158)
- E C Choi (ORCID: https://orcid.org/0009-0001-2104-2256)
Institutions
- Dalhousie University (CA)
- Sunnybrook Health Science Centre (CA)
- University of Toronto (CA)
- McMaster University Medical Centre (CA)
- Health Sciences Centre (CA)
Publication Details
- Journal
- The Journal of Infectious Diseases
- Published
- 2025-11-14
- DOI
- https://doi.org/10.1093/infdis/jiaf585
- Primary Topic
- Antibiotic Resistance in Bacteria
- Type
- article
- Field-Weighted Citation Impact
- 0.00