Synthesis of azepino[4,5- <i>b</i> ]indoles and benzo[ <i>f</i> ][1,5]diazecine-2,8(1 <i>H</i> ,3 <i>H</i> )diones: promising anti-cancer activity toward cervical and brain cancer
A regio- and stereoselective route to azepino[4,5- b ]indoles is reported, with unprecedented formation of tetrahydrobenzo[ f ][1,5]diazecine-2,8(1 H ,3 H )diones. The diazecine compounds show anti-cancer activity against HeLa and U87MG cell lines.
Authors
- Manas K. Ghorai (ORCID: https://orcid.org/0000-0002-0472-4757)
- Prabodh Ranjan (ORCID: https://orcid.org/0000-0002-7991-9217)
- Gaurav Goswami (ORCID: https://orcid.org/0000-0001-8492-2181)
- Suraj Kashyap (ORCID: https://orcid.org/0000-0001-5319-7036)
- Seema Sen (ORCID: https://orcid.org/0000-0001-9649-9616)
- Ritika Gautam Singh (ORCID: https://orcid.org/0000-0001-5826-0719)
- Ashwini Kumar (ORCID: https://orcid.org/0000-0002-4696-4652)
- Bharat Singh (ORCID: https://orcid.org/0000-0003-2865-5829)
- Preeti Chahar
- Ranajit Mal
Institutions
- Presidency University (IN)
- Indian Institute of Technology Kanpur (IN)
Publication Details
- Journal
- Organic Chemistry Frontiers
- Published
- 2025-11-13
- DOI
- https://doi.org/10.1039/d5qo01306b
- Citations
- 1
- Primary Topic
- Synthesis and pharmacology of benzodiazepine derivatives
- Type
- article
- Field-Weighted Citation Impact
- 0.94