Enhancing Chimeric Fragmentation Spectra Deconvolution Using Direct Infusion–Tandem Mass Spectrometry Across High‐Resolution Mass Spectrometric Platforms
These findings indicate that the DI-MS2 is a robust and flexible method applicable across different MS platforms, though the Q-Orbitrap may be less suited for highly complex samples with multiple peaks per nominal mass. This highlights the potential of the DI-MS2 for structural elucidation of complex biological mixtures. Additionally, we provide initial setting optimisation guidelines to improve spectra deconvolution and measurement speed.
Authors
- Carsten Simon (ORCID: https://orcid.org/0000-0003-3882-3013)
- Sebastian Böcker (ORCID: https://orcid.org/0000-0002-9304-8091)
- Gerd Gleixner (ORCID: https://orcid.org/0000-0002-4616-0953)
- Kai Dührkop (ORCID: https://orcid.org/0000-0002-9056-0540)
- Arina Ivanova (ORCID: https://orcid.org/0000-0003-0591-9334)
- Wei Tang (ORCID: https://orcid.org/0000-0001-8811-4798)
Institutions
- Max Planck Institute for Biogeochemistry (DE)
- Friedrich Schiller University Jena (DE)
Publication Details
- Journal
- Rapid Communications in Mass Spectrometry
- Published
- 2025-11-16
- DOI
- https://doi.org/10.1002/rcm.10170
- Citations
- 1
- Primary Topic
- Mass Spectrometry Techniques and Applications
- Type
- article
- Field-Weighted Citation Impact
- 0.76
Funders
- Deutsche Forschungsgemeinschaft