Doppler Ultrasound Detection and Grading of Portal Vein Thrombosis in Patients with Liver Cirrhosis: Results from a Cross-Sectional Study, Abbottabad

Objective: To ascertain the portal vein thrombosis frequency via ultrasound in liver cirrhosis patients at theCombined Military Hospital, Abbottabad.Study Design: Cross-sectional study.Place and Duration of Study: This study was conducted at the Department of Radiology, Combined MilitaryHospital (CMH), Abbottabad, Pakistan from 29th December 2023 to 29th June 2024.Methods: The study utilized a sequential sampling strategy to recruit participants, excluding those withhepatocellular carcinoma, coagulopathies, malignancy, infections, or pregnancy. Doppler ultrasound assessedportal vein thrombosis, with pertinent clinical and laboratory data being recorded. Data analysis wasperformed using SPSS v25, considering P ≤ 0.05 as significant.Results: This study involving 137 patients revealed a mean age of 43.52 ± 15.08 years. The average duration ofliver cirrhosis was 3.9 ± 1.29 months. Patients had a mean serum albumin level of 2.31 ± 0.24 g/dL and a meanprothrombin time/international normalized ratio (INR) of 1.40 ± 0.11 seconds. Chronic viral hepatitis wasidentified as the leading cause of liver disease, accounting for 33.6% of cases. Other causes included nonalcoholic fatty liver disease (NAFLD) 20.4%, autoimmune hepatitis 19.7%, and drug-induced liver injury 15.3%. Portal vein thrombosis was found in 17 patients (12.4%), with Grade I being the most common type, accounting for 4.4%, followed by Grade II and Grade III, be 3.6% & 2.9%, respectively.Conclusion: This study demonstrates a notable prevalence of portal vein thrombosis (PVT) (12.4%) in cirrhoticpatients, underscoring the critical role of Doppler ultrasound as a non-invasive, accessible tool for earlydetection and grading of PVT. How to cite this: Khan M, Hasnain MAZ, Khan S, Ahmad MI. Doppler Ultrasound Detection and Grading of Portal Vein Thrombosis in Patients with Liver Cirrhosis: Results from a Cross-Sectional Study, Abbottabad. Life and Science. 2025; 6(4): 490-496. doi: http://doi.org/10.37185/LnS.1.1.973