Effectiveness of Dual Versus Triple Inhaled Therapy in Chronic Obstructive Pulmonary Disease Patients: Results from a Quasi-Experimental Study, Multan

Objective: To compare the efficacy of dual inhaled therapy and triple inhaled therapy in chronic obstructivepulmonary disease patients.Study Design: Quasi-experimental study.Place and Duration of Study: This study was conducted at the Department of Medicine, Combined MilitaryHospital (CMH), Multan, Pakistan from 1st January 2023 to 31st December 2023.Methods: A total of 60 patients with chronic obstructive pulmonary disease were included in this study andallocated to 2 equal groups based on clinical criteria. In Group-D, patients were given dual inhaled inhalertherapy (Corticosteroid+ Long acting β-2 agonists) while patients in Group-T were given triple inhaled inhalertherapy (Corticosteroid+ Long acting β-2 agonists+ long-acting muscarinic antagonist) twice daily. The primaryoutcome was set as the percentage of patients achieving a reduced number of moderate-severe exacerbations,while the secondary outcomes included improved post-dose forced expiratory volume, number of patientsachieving improved chronic obstructive pulmonary disease assessment test score, and baseline dyspnea indexfocal score after 6 months of treatment.Results: The results of primary outcomes showed significantly better efficacy in Group-T compared to Group-D,as a considerably higher number of patients had reduced frequency of moderate-severe chronic obstructivepulmonary disease exacerbations after 6 months (86.66% vs 53.33%, P=0.035).There was also significant improvement in secondary outcomes, including post-dose forced expiratory volumein 1 second, patients who had improved assessment test scores, as well as baseline dyspnea index focal score inGroup-T compared to Group-D.Conclusion: Triple inhaled therapy is more effective than dual inhaled therapy for reducing moderate-to-severechronic obstructive pulmonary disease exacerbations. How to cite this: Batool S, Khan JA, Asmat F, Wajid H, Hashmi Z. Effectiveness of Dual Versus Triple Inhaled Therapy in Chronic Obstructive Pulmonary Disease Patients: Results from a Quasi-Experimental Study, Multan. Life and Science. 2025; 6(4): 430-436. doi: http://doi.org/10.37185/LnS.1.1.763