Diagnostic Accuracy of the Clinical Assessment of Chorioamnionitis Compared with Histological Findings: A Cross-Sectional Study at Private Healthcare Setting, Multan

Objective: To determine the diagnostic accuracy of clinical diagnosis of chorioamnionitis by comparing it withhistopathological findings in a tertiary care hospital setting.Study Design: A cross-sectional study.Place and Duration of Study: This study was conducted at the Department of Obstetrics and Gynaecology inIbn-e-Siena Hospital, Multan, Pakistan from 3rd July 2024 to 3rd January 2025.Methods: A total of sixty pregnant women with singleton pregnancies at gestational age >28 weeks, whofulfilled the clinical diagnostic criteria for chorioamnionitis, were included. Following delivery, placentas weresent for histopathological examination. The placental tissues were fixed in 10% buffered formalin, processed,and stained with haematoxylins and eosin. The histological diagnosis of chorioamnionitis was made based onestablished microscopic criteria, including the presence of acute inflammatory infiltrates in the chorion,amnion, or umbilical cord. Data were analyzed using SPSS version 25 to assess diagnostic accuracy and thepredictive value of individual clinical features.Results: Of 60 clinically diagnosed cases, histological confirmation was observed in 39 (65%), while 21 patients(35%) did not show histological evidence of infection/inflammation. This reflects a diagnostic accuracy of 65%for clinical diagnosis compared to the histopathological gold standard. Fetal tachycardia (PPV: 76.2%), foulsmelling vaginal discharge (PPV: 78.6%), and PROM >24 hours (PPV: 78.9%) were strong predictors ofhistological chorioamnionitis, significantly increasing the likelihood of actual intra-amniotic infection.However, clinical features such as maternal tachycardia and uterine tenderness showed moderate predictivevalue.Conclusion: The clinical diagnosis of chorioamnionitis showed a moderate correlation with histologicalfindings. Incorporating histopathology in diagnostic workups can enhance diagnostic accuracy and helpoptimize the management of suspected intra-amniotic infections. How to cite this: Tauseef H, Haider F, Akhtar F. Diagnostic Accuracy of the Clinical Assessment of Chorioamnionitis Compared with Histological Findings: A Cross-Sectional Study at Private Healthcare Setting, Multan. Life and Science. 2025; 6(4): 504-509. doi: http://doi.org/10.37185/LnS.1.1.968