KDM1A Facilitates Oncogenic Potential in Colorectal Cancer Progression Through the Activation of AXIN/GSK3β/β‐Catenin Signaling Pathways: Evidence From Integrated Transcriptomics and In Vitro Studies
KDM1A regulates CRC progression by modulating epithelial-mesenchymal transition (EMT), metabolism, and Wnt signaling. Targeting KDM1A with GSK2879552 represents a promising therapeutic strategy for CRC treatment.
Authors
- Sathan Raj Natarajan (ORCID: https://orcid.org/0000-0001-9675-7582)
- Ponnulakshmi Rajagopal (ORCID: https://orcid.org/0000-0003-1361-3386)
- Mansour K. Gatasheh (ORCID: https://orcid.org/0000-0002-0101-1014)
- Chella Perumal Palanisamy (ORCID: https://orcid.org/0000-0002-3527-3477)
- Vishnu Priya Veeraraghavan (ORCID: https://orcid.org/0000-0002-5071-9860)
- Selvaraj Jayaraman (ORCID: https://orcid.org/0009-0008-2557-1471)
- Mohammad A. Alshuniaber (ORCID: https://orcid.org/0000-0001-6358-0653)
- Rajapandiyan Krishnamoorthy (ORCID: https://orcid.org/0000-0002-3728-1120)
Institutions
- King Saud University (SA)
- Meenakshi Academy of Higher Education and Research (IN)
- Saveetha University (IN)
Publication Details
- Journal
- The Journal of Gene Medicine
- Published
- 2025-11-01
- DOI
- https://doi.org/10.1002/jgm.70053
- Primary Topic
- Cancer Cells and Metastasis
- Type
- article
- Field-Weighted Citation Impact
- 0.00