SIRT1 Enhancement is Required for the Induction of Anti-Inflammatory Effect of Micheliolide in Carbon Tetrachloride Induced Liver Fibrosis in Mice
MCL mitigates CCl<sub>4</sub>-induced liver injury and fibrosis by activating SIRT1 to suppress liver inflammation in mice. These findings uncover a novel molecular mechanism for the anti-liver fibrotic activity of MCL and highlight its potential as a therapeutic candidate for liver fibrosis.
Authors
- Yirong Hu (ORCID: https://orcid.org/0000-0001-7434-5982)
- Chengyu Jin (ORCID: https://orcid.org/0000-0002-9370-9240)
- Aoqing Jiang
- Hongyan Wu (ORCID: https://orcid.org/0000-0002-6887-2548)
- Zhaoguo Liu (ORCID: https://orcid.org/0000-0001-6311-8338)
- Jeffrey P. Chang
- Jianhua Shi (ORCID: https://orcid.org/0000-0003-4509-5253)
- Rui Zhao (ORCID: https://orcid.org/0009-0009-3031-8435)
- Zhiying Han
- Yichen Wang (ORCID: https://orcid.org/0009-0003-9211-0919)
Institutions
- Nantong University (CN)
- Jiangsu Vocational College of Medicine (CN)
- Yancheng Institute of Technology (CN)
Publication Details
- Journal
- Journal of Inflammation Research
- Published
- 2025-11-01
- DOI
- https://doi.org/10.2147/jir.s559076
- Primary Topic
- Liver physiology and pathology
- Type
- article
- Field-Weighted Citation Impact
- 0.00