Cationic Liposome-Mediated Bcl-2 Gene Transfection in Bone Marrow Mesenchymal Stem Cells: A Novel Regenerative Approach for Spinal Cord Injury
Transplantation of Bcl-2-transfected BMSCs represents a highly promising strategy that effectively promotes neural regeneration, inhibits scar formation, reduces demyelination, and enhances functional recovery, highlighting its potential for clinical translation.
Authors
- Xiaojun Feng (ORCID: https://orcid.org/0000-0002-7436-6967)
- Xin Zhou (ORCID: https://orcid.org/0000-0002-6566-9018)
- Haitao Yuan (ORCID: https://orcid.org/0000-0001-6141-7254)
- Tianqi Wang (ORCID: https://orcid.org/0000-0002-1460-1013)
- Bo Chu (ORCID: https://orcid.org/0000-0002-3659-5670)
- Kamran Hidayat Ullah (ORCID: https://orcid.org/0000-0001-7160-546X)
- Jun Gu (ORCID: https://orcid.org/0009-0003-4494-3932)
Institutions
- CECOS University (PK)
- Wuxi People's Hospital (CN)
Publication Details
- Journal
- Drug Design Development and Therapy
- Published
- 2025-11-01
- DOI
- https://doi.org/10.2147/dddt.s513105
- Primary Topic
- Mesenchymal stem cell research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Jiangsu Commission of Health