KIF20A immunohistochemical expression in urothelial carcinoma of urinary bladder in Egyptian patients

Introduction: Urothelial bladder cancer, a prevalent malignancy worldwide, poses significant challenges in diagnosis and prognosis due to its complex and multifactorial etiology. Aim of the study: This article comprehensively studies the production of Kinesin family member 20A (KIF20A), a well-established oncogene implicated in various human cancers, within the context of urothelial bladder carcinoma. Furthermore, we sought to study potential correlations of KIF20A production to a range of clinicopathological parameters to evaluate its utility as a diagnostic or prognostic biomarker. Subjects and Methods: Immunohistochemical analysis of KIF20A was conducted on a cohort of 60 archived paraffin-embedded bladder cancer tissue samples. Results: Our findings revealed high KIF20A expression in 60% (36/60) of the cases, exhibiting both cytoplasmic and membranous staining patterns. KIF20A expression showed significant correlations with several clinicopathological factors. A strong association was observed with tumor grade (p=0.001) and pathological T stage (p=0.001). Vascular embolism also correlated significantly with KIF20A expression (p=0.000), as did perineural invasion (p=0.025). Furthermore, KIF20A expression levels were significantly associated with tumor location within the bladder (p=0.027).Conclusion: These results introduces KIF20A as a valuable biomarker for bladder cancer, potentially aiding in risk stratification and treatment decision-making.