Evaluation of serum vitamin D3 before and after intralesional injection of vitamin D3 in patients with alopecia areata

This study investigates the effect of intralesional vitamin D3 injections on serum 25-hydroxyvitamin D3 levels in patients with localized patchy alopecia areata. Twenty adults received three intralesional sessions over nine weeks. Results showed a significant increase in serum vitamin D3 levels from 9.31 ng/mL to 23.55 ng/mL (p = 0.001). The proportion of deficient patients dropped from 85% to 30%, while those with optimal levels rose from 10% to 35% (p = 0.012). Despite these improvements, no significant correlation was observed between baseline vitamin D3 levels and the severity of alopecia areata (rho = 0.368, p = 0.110). The findings suggest that intralesional vitamin D3 is not only effective in improving systemic vitamin D3 status but also offers therapeutic potential for alopecia areata, although baseline serum levels are not predictive of disease severity or treatment response.Keywords: Alopecia areata, Intralesional vitamin D3, Serum 25(OH)D, Hair loss therapy, Autoimmune skin disorder