Effect of Moringa Oleifera Leaves Extract on Some Biochemical Responses of Diclofenac Treated Rats

Background: Diclofenac sodium (DcNa) is one of non-steroidal anti-inflammatory drugs (NSAIDs) medicines which used to reduce pain and inflammatory condition. Aim of the work: The current study design to evaluate the possibility of Moringa oleifera (MO) leaves extract to improve the harmful effects of DcNa on different physiological parameters in albino rats. Methods: The study included 35 rats divided io to 5 groups: group I (control group), group II (DcNa group) animals treated with 10 mg of DcNa /kg b.w. daily, group III (MO groups) rats were treated with 350 mg of MO leaves extract /kg b.w., group IV (treated with DcNa then MO leaves extract) and group V (treated with MO leaves then DcNa). Results: The obtained results indicated that, treatment with diclofenac sodium showed significant decreases in antioxidant enzyme activities and significant increases in serum liver parameters, kidney function and lipid profile parameters. Moringa oleifera leaves extract administration to DcNa group caused an improvement in liver parameters and kidney functions, oxidative stress and lipid profile. Conclusion: Administration of diclofenac induced some adverse effects on some physiological parameters, which may be attributed to the oxidative stress induced by DcNa. MO leaves extract helps in ameliorate the negative effects caused by diclofenac sodium.