Engineered Cancer Cell Membrane-Functionalized Metal-Organic Frameworks for Irinotecan/Curcumin Codelivery in Colorectal Cancer: Enhanced Efficacy and Mitigated Toxicity
Our strategy effectively alleviates CPT-11-induced intestinal toxicity and mitigates adverse reactions. This approach may provide a novel method for enhancing chemotherapeutic efficacy while reducing gastrointestinal toxicity.
Authors
- Shuiling Jin (ORCID: https://orcid.org/0000-0001-7330-7140)
- Xintong Dong (ORCID: https://orcid.org/0000-0002-6887-8712)
- Hong‐Min Meng (ORCID: https://orcid.org/0000-0003-0723-1242)
- Zhengquan Yu (ORCID: https://orcid.org/0000-0001-8696-2013)
- Di Zhao (ORCID: https://orcid.org/0000-0002-8630-8908)
- Zhaohui Li (ORCID: https://orcid.org/0000-0003-3946-0656)
- Qi Zhang (ORCID: https://orcid.org/0000-0002-9065-7772)
- Aifang Zhou
Institutions
- Zhengzhou University (CN)
- First Affiliated Hospital of Zhengzhou University (CN)
Publication Details
- Journal
- International Journal of Nanomedicine
- Published
- 2025-11-01
- DOI
- https://doi.org/10.2147/ijn.s558675
- Citations
- 2
- Primary Topic
- Curcumin's Biomedical Applications
- Type
- article
- Field-Weighted Citation Impact
- 1.18
Funders
- National Natural Science Foundation of China
- National Key Research and Development Program of China