JNK knockdown enhances CAR-T cell cytotoxicity through elevated NFATc1-dependent transcription in preclinical ovarian cancer models
JNK signaling is a significant regulator of CAR-T cell cytotoxicity, offering a potential strategy to directly enhance CAR-T effectiveness in human cancer therapies.
Authors
- Chloe E Jepson
- Charles J. Kuhlmann (ORCID: https://orcid.org/0000-0003-4438-5814)
- Madison T Blucas
- Masakazu Kamata (ORCID: https://orcid.org/0000-0003-0323-3742)
- Yoshiko N Kamata
- Fatema M Suleiman
- Anusha Manda
Institutions
- University of Alabama at Birmingham (US)
Publication Details
- Journal
- Journal for ImmunoTherapy of Cancer
- Published
- 2025-11-01
- DOI
- https://doi.org/10.1136/jitc-2025-012968
- Primary Topic
- CAR-T cell therapy research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Center for AIDS Research, University of Washington