Oncolytic virus-induced IL-1β <sup>+</sup> monocyte-IL-6 <sup>+</sup> CAF axis suppresses dendritic cell-mediated antitumor immunity in pancreatic cancer
Our findings reveal a previously unrecognized monocyte-CAF-DC axis that mediates resistance to OV therapy through IL-1β and IL-6-driven suppression of DC function in PDAC. This study provides a mechanistically informed and translationally promising approach to overcome stromal immune suppression, restore effective antitumor immunity, and improve therapeutic outcomes for patients with PDAC.
Authors
- Youjia Cao (ORCID: https://orcid.org/0000-0003-2077-1999)
- Jiangmei Li
- Zhaoyuan Zhang (ORCID: https://orcid.org/0009-0005-3649-123X)
- Feilong Zhou (ORCID: https://orcid.org/0009-0003-3347-8529)
- Jingwei Yu (ORCID: https://orcid.org/0000-0002-7587-754X)
- Jingru Chen (ORCID: https://orcid.org/0000-0001-9317-906X)
- Han Wang (ORCID: https://orcid.org/0009-0004-5583-0121)
- Song Xu (ORCID: https://orcid.org/0000-0001-6153-387X)
- Shiyu Liu (ORCID: https://orcid.org/0000-0001-8177-3985)
- Yi Wang (ORCID: https://orcid.org/0000-0002-1832-0876)
- Fan Li (ORCID: https://orcid.org/0000-0001-5449-6812)
- Wei Wang (ORCID: https://orcid.org/0000-0001-8167-4899)
- Zhen Zhao (ORCID: https://orcid.org/0000-0003-0044-5512)
- Jie Wang (ORCID: https://orcid.org/0000-0001-7870-0646)
- Zhigang Zhao (ORCID: https://orcid.org/0000-0002-9327-9893)
- Hongkai Zhang (ORCID: https://orcid.org/0000-0003-2186-5508)
- Yi Yang (ORCID: https://orcid.org/0000-0002-5200-0614)
- Yuanke Li (ORCID: https://orcid.org/0000-0002-8304-8768)
- Li Deng (ORCID: https://orcid.org/0000-0003-1638-1867)
- Minghui Han
- Yajuan Wan
Institutions
- Chinese University of Hong Kong (HK)
- Hebei University of Technology (CN)
- Nankai University (CN)
- Fudan University (CN)
- Tianjin First Center Hospital (CN)
- Sinovac Biotech (CN)
- Tianjin Medical University General Hospital (CN)
- ShanghaiTech University (CN)
- National Vaccine and Serum Institute (CN)
- Zhongshan Hospital (CN)
- Tianjin Medical University (CN)
Publication Details
- Journal
- Journal for ImmunoTherapy of Cancer
- Published
- 2025-11-01
- DOI
- https://doi.org/10.1136/jitc-2025-013175
- Citations
- 2
- Primary Topic
- Immunotherapy and Immune Responses
- Type
- article
- Field-Weighted Citation Impact
- 1.59
Funders
- National Natural Science Foundation of China
- Nankai University
- Tianjin Medical University
- ShanghaiTech University
- China National Biotec Group Company