Novel antibodies for identification, selection, and manipulation of T cells expressing Whitlow linker-containing CARs
Anti-Whitlow mAb clones exhibited distinct structural and functional properties that can be leveraged for multiple applications, providing versatile tools for detection, selection and manipulation of a broad range of clinical and preclinical CAR T-cell products.
Authors
- David Jellyman
- Jordan Gauthier (ORCID: https://orcid.org/0000-0002-5769-8409)
- Erik L. Kimble (ORCID: https://orcid.org/0000-0002-1885-1773)
- Delaney R. Kirchmeier
- Brandon Seaton
- Aiko Torkelson
- Raymond Ruff (ORCID: https://orcid.org/0000-0002-7189-1221)
- Alexandre V. Hirayama (ORCID: https://orcid.org/0000-0001-7980-3882)
- Norman Boiani
- Orpheus Kolokythas (ORCID: https://orcid.org/0000-0001-6707-9962)
- Eric M. Tam (ORCID: https://orcid.org/0000-0001-8981-1106)
- Cecilia C.S. Yeung (ORCID: https://orcid.org/0000-0001-6799-2022)
- Cameron J. Turtle (ORCID: https://orcid.org/0000-0002-4722-4461)
- Kristen R Shimp
- Jocelyn H. Wright (ORCID: https://orcid.org/0000-0003-1548-0847)
- Jason P. Price
- Kristina Braathen (ORCID: https://orcid.org/0009-0003-5362-1556)
Institutions
- The University of Sydney (AU)
- University of Washington (US)
- Fred Hutch Cancer Center (US)
- Center for Cancer and Blood Disorders (US)
Publication Details
- Journal
- Journal for ImmunoTherapy of Cancer
- Published
- 2025-11-01
- DOI
- https://doi.org/10.1136/jitc-2025-013123
- Primary Topic
- CAR-T cell therapy research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Fred Hutchinson Cancer Research Center