Elevated ITGAV Expression in Seropositive Rheumatoid Arthritis: Diagnostic Potential and Immunopathological Insights
<i>ITGAV</i> is significantly upregulated in seropositive RA and exhibits potential as a non-invasive biomarker for disease diagnosis and stratification. Its preferential expression in inflammatory immune cell subsets and association with subclinical synovial inflammation highlight its promise as both a diagnostic and mechanistic target in RA. Future longitudinal and functional studies are warranted to validate its role in personalized disease management.
Authors
- Chenyang Song
- Yu Shan (ORCID: https://orcid.org/0000-0003-0979-695X)
- Yixin Zheng
- Jianan Zhao (ORCID: https://orcid.org/0000-0002-8439-1082)
- Cen Chang (ORCID: https://orcid.org/0000-0002-7449-2613)
- Hongliang Hu (ORCID: https://orcid.org/0009-0000-9653-4370)
- Dongyi He (ORCID: https://orcid.org/0000-0001-7975-3870)
- Yaxin Cheng
- Yiming Shi (ORCID: https://orcid.org/0000-0001-6620-6034)
- Yunshen Li
- Fuyu Zhao (ORCID: https://orcid.org/0000-0002-2425-5388)
Institutions
- Shanghai University of Traditional Chinese Medicine (CN)
- Longhua Hospital Shanghai University of Traditional Chinese Medicine (CN)
- Shanghai Guanghua Hospital of Integrated Traditional Chinese and Western Medicine (CN)
- Shanghai Institute of Applied Physics (CN)
Publication Details
- Journal
- Journal of Inflammation Research
- Published
- 2025-11-01
- DOI
- https://doi.org/10.2147/jir.s540469
- Primary Topic
- Rheumatoid Arthritis Research and Therapies
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- State Administration of Traditional Chinese Medicine of the People's Republic of China