Cross-Disease Identification of FBP1 in Atherosclerosis and Calcific Aortic Valve Disease via Integrated Bioinformatics and Validation: Functional Analysis and Therapeutic Target Exploration
FBP1 represents a shared immunometabolic biomarker and potential therapeutic target that links metabolic reprogramming to immune dysregulation in AS and CAVD. These findings provide a rationale for further translational studies evaluating FBP1-centered interventions.
Authors
- Jinpeng Wu
- Mingjin Guo (ORCID: https://orcid.org/0009-0006-6223-4808)
- Yifan Xu (ORCID: https://orcid.org/0000-0002-3425-6843)
- Zhisheng Yan (ORCID: https://orcid.org/0000-0002-6722-5517)
- Yongxin Li (ORCID: https://orcid.org/0000-0003-1511-4599)
- Xueyi Wang (ORCID: https://orcid.org/0000-0002-0798-2049)
- Ting Geng (ORCID: https://orcid.org/0000-0002-0235-3112)
- Haowen Xu (ORCID: https://orcid.org/0009-0001-5686-6810)
Institutions
- Qingdao University (CN)
- Affiliated Hospital of Qingdao University (CN)
- Rongcheng City People's Hospital (CN)
- Qingdao Eighth People's Hospital (CN)
Publication Details
- Journal
- Journal of Inflammation Research
- Published
- 2025-11-01
- DOI
- https://doi.org/10.2147/jir.s540540
- Primary Topic
- Connective tissue disorders research
- Type
- article
- Field-Weighted Citation Impact
- 0.00