Integrative Bulk and Single-Cell Transcriptome Analyses Reveal Mitochondrial Metabolism-Related Biomarkers in IgA Nephropathy with Experimental Validation
This study integrated bulk and scRNA-seq analyses to pinpoint CYP27B1 and PCK1 as biomarkers, with PTCs identified as key cells, providing novel diagnostic approaches for IgAN.
Authors
- Xuedan Nie (ORCID: https://orcid.org/0009-0008-1042-9915)
- Yeping Ren (ORCID: https://orcid.org/0000-0002-5450-180X)
- Dan Li (ORCID: https://orcid.org/0009-0009-1386-7643)
- Hao Liu (ORCID: https://orcid.org/0000-0002-5620-4948)
- Qin Wang (ORCID: https://orcid.org/0009-0004-6997-0678)
- Ibtasam Wajid (ORCID: https://orcid.org/0009-0009-4013-279X)
Institutions
- Shenzhen University (CN)
- University Town of Shenzhen (CN)
- ShenZhen People’s Hospital (CN)
- Shenzhen University Health Science Center (CN)
Publication Details
- Journal
- Journal of Inflammation Research
- Published
- 2025-11-01
- DOI
- https://doi.org/10.2147/jir.s565202
- Primary Topic
- Single-cell and spatial transcriptomics
- Type
- article
- Field-Weighted Citation Impact
- 0.00