Resolvin D1 alleviates lipopolysaccharide-induced <i>in vitro</i> corneal inflammation by modulating macrophage polarization through upregulation of c-Fos expression
Our findings reveal that RvD1 conferred protective effects against LPS-induced inflammation by enhancing M2 macrophage polarization through the promotion of c-Fos expression. Thus, RvD1 may be a potential therapeutic compound for enhancing corneal fibroblast proliferation and migration while attenuating inflammation.
Authors
- Yinru Wang
- Zhenggao Xie (ORCID: https://orcid.org/0000-0002-2587-157X)
- Zifang He (ORCID: https://orcid.org/0000-0002-2526-6505)
- Xinxuan Cheng (ORCID: https://orcid.org/0000-0001-8975-7621)
- Weiwei An (ORCID: https://orcid.org/0009-0006-0788-3629)
- Feifei Chen (ORCID: https://orcid.org/0000-0001-7175-9119)
- Yajun Liu (ORCID: https://orcid.org/0009-0005-8446-0972)
- Qin Qin (ORCID: https://orcid.org/0000-0002-1176-1601)
- Deyan Chen (ORCID: https://orcid.org/0000-0001-7351-4617)
Institutions
- Nanjing University of Chinese Medicine (CN)
- Bengbu Medical College (CN)
- Nanjing Traditional Chinese Medicine Hospital (CN)
- Nanjing Drum Tower Hospital (CN)
- Yancheng Third People's Hospital (CN)
Publication Details
- Journal
- Bioimpacts
- Published
- 2025-11-15
- DOI
- https://doi.org/10.34172/bi.32639
- Primary Topic
- Fatty Acid Research and Health
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Jiangsu Commission of Health
- Nanjing University
- Nanjing Drum Tower Hospital