Spatial ecostructural modelling of endometrial cancer identifies the key role of CD90 + CD105 + endothelial cells in tumour heterogeneity and predicts disease recurrence
Our study establishes a spatial eco-context framework for molecular subtypes of endometrial cancer by integrating single-cell spatial multiomics data. This approach enables high-resolution mapping of tumour-immune-stromal interaction networks and reveals novel targets for personalized therapeutic strategies.
Authors
- Mingxia Ye (ORCID: https://orcid.org/0000-0003-4741-0026)
- Di Wu (ORCID: https://orcid.org/0000-0002-8109-5368)
- Qingzhi Zhai (ORCID: https://orcid.org/0000-0002-7328-2948)
- Nan Wang (ORCID: https://orcid.org/0000-0001-8788-2517)
- Mingyang Wang (ORCID: https://orcid.org/0000-0001-7201-5090)
- Zhifeng Yan (ORCID: https://orcid.org/0000-0002-6930-3128)
- Zheng Wang (ORCID: https://orcid.org/0000-0003-4838-0965)
- Luyang Zhao
- Mingxia Li (ORCID: https://orcid.org/0000-0002-6941-7344)
- Yuanguang Meng (ORCID: https://orcid.org/0000-0003-3813-8411)
- Lv Chen (ORCID: https://orcid.org/0000-0001-5488-0427)
- Lian Li (ORCID: https://orcid.org/0000-0001-8628-4101)
Institutions
- Nankai University (CN)
- Chinese PLA General Hospital (CN)
- Tsinghua University (CN)
Publication Details
- Journal
- Experimental Hematology and Oncology
- Published
- 2025-11-16
- DOI
- https://doi.org/10.1186/s40164-025-00724-6
- Citations
- 1
- Primary Topic
- Single-cell and spatial transcriptomics
- Type
- article
- Field-Weighted Citation Impact
- 0.81
Funders
- National Natural Science Foundation of China