Pathways Contributing to Chemotherapy‐Induced Myotoxicity Are Attenuated by EPA + DHA in a Clinically Relevant Model of Colorectal Cancer

Chemotherapy negatively impacts processes involved in muscle homeostasis, including muscle cell proliferation and regeneration. The provision of fish oil primarily showed protective effects from pro-inflammatory mediators by downregulating genes involved in the leukocyte extravasation pathway. Our findings provide novel insights into the molecular mechanisms underlying chemotherapy-induced myotoxicity and the potential therapeutic benefits of dietary EPA + DHA to restore muscle homeostasis in cancer.