Aerobic Exercise Training Exerts Neuroprotective Effects in Alzheimer's Disease Mice by Regulating Endoplasmic Reticulum Stress‐Autophagy Pathway‐Mediated Pyroptosis
AET reduces NLRP3 inflammasome-mediated pyroptosis and neuronal damage in the hippocampal CA1 region of AD mice by regulating the ERS-autophagy pathway through the inhibition of the PERK-eIF2α pathway, thereby improving cognitive function in AD mice.
Authors
- Shaowen Yu
- Y. Yu (ORCID: https://orcid.org/0009-0004-2988-0440)
- Biao He
- X H Sun (ORCID: https://orcid.org/0009-0005-6510-9298)
- Yunliang Wang (ORCID: https://orcid.org/0009-0006-6942-0814)
Institutions
- Wannan Medical College (CN)
- First Affiliated Hospital of Wannan Medical College (CN)
- Anhui Normal University (CN)
Publication Details
- Journal
- CNS Neuroscience & Therapeutics
- Published
- 2025-11-01
- DOI
- https://doi.org/10.1111/cns.70620
- Citations
- 1
- Primary Topic
- Inflammasome and immune disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.81