Distinct osteoclastogenic potential of granulocyte-macrophage colony-stimulating factor-induced monocyte subsets
moDCs exhibit limited potential as osteoclast precursors under inflammatory conditions. Comparatively, GM-CSF (+ TNF-α)-induced progenitors represent a more viable inflammatory osteoclast precursor population. Overall, our results provide insights into osteoclast heterogeneity and RA-associated bone destruction mechanisms.
Authors
- Kojiro Sato (ORCID: https://orcid.org/0000-0003-4105-3726)
- Shigeru Kinoshita (ORCID: https://orcid.org/0000-0002-6839-251X)
- Yasuhiro Omata
Institutions
- Jichi Medical University (JP)
Publication Details
- Journal
- Bone Reports
- Published
- 2025-11-10
- DOI
- https://doi.org/10.1016/j.bonr.2025.101886
- Primary Topic
- Bone Metabolism and Diseases
- Type
- article
- Field-Weighted Citation Impact
- 0.00