Neuroanatomical dimensions in major depression linked to cognition, adverse life events, self-harm, metabolomics and genetics
D1 and D2 represent distinct neurobiological mechanisms underlying MDD. The validation in a general population-based cohort and in a cohort sample with depressive symptoms delineates mechanisms underlying heterogeneity in MDD.
Authors
- Beata R. Godlewska (ORCID: https://orcid.org/0000-0002-5973-3765)
- Ashish Singh (ORCID: https://orcid.org/0000-0003-4486-3636)
- Irina A. Strigo (ORCID: https://orcid.org/0000-0002-8799-716X)
- Yuhan Cui (ORCID: https://orcid.org/0000-0002-0017-0056)
- Andrew Mark McIntosh (ORCID: https://orcid.org/0000-0002-0198-4588)
- Duygu Tosun (ORCID: https://orcid.org/0000-0001-8644-7724)
- Wenyi Xiao (ORCID: https://orcid.org/0009-0005-3387-1173)
- Stephen C. Strother (ORCID: https://orcid.org/0000-0002-3198-217X)
- Chao‐Gan Yan (ORCID: https://orcid.org/0000-0003-3413-5977)
- J.F.W. Deakin (ORCID: https://orcid.org/0000-0002-2750-962X)
- Rachel D. Woodham (ORCID: https://orcid.org/0000-0002-5581-9449)
- Dongtao Wei (ORCID: https://orcid.org/0000-0003-2544-8015)
- Catherine J. Harmer (ORCID: https://orcid.org/0000-0002-1609-8335)
- Gitte M. Knudsen (ORCID: https://orcid.org/0000-0003-1508-6866)
- Cynthia H.Y. Fu (ORCID: https://orcid.org/0000-0003-4313-3500)
- Mathilde Antoniades (ORCID: https://orcid.org/0000-0002-8241-835X)
- Helen S. Mayberg (ORCID: https://orcid.org/0000-0002-1672-2716)
- Susan Rotzinger (ORCID: https://orcid.org/0000-0003-1980-3674)
- Stephen R. Arnott (ORCID: https://orcid.org/0000-0002-0616-7771)
- Güray Erus (ORCID: https://orcid.org/0000-0001-6633-4861)
- Vibe G. Frøkjær (ORCID: https://orcid.org/0000-0002-9321-2365)
- Melanie Ganz (ORCID: https://orcid.org/0000-0002-9120-8098)
- Yong Fan (ORCID: https://orcid.org/0000-0001-9869-4685)
- Jonathan Savitz (ORCID: https://orcid.org/0000-0001-8143-182X)
- Christos A. Davatzikos (ORCID: https://orcid.org/0000-0002-1025-8561)
- Sidney H. Kennedy (ORCID: https://orcid.org/0000-0001-5339-7185)
- Aleks Stolicyn (ORCID: https://orcid.org/0000-0002-1147-7539)
- Ian H. Gotlib (ORCID: https://orcid.org/0000-0002-3622-3199)
- Boadie W. Dunlop (ORCID: https://orcid.org/0000-0002-4653-0483)
- Haochang Shou
- Allan H. Young (ORCID: https://orcid.org/0000-0003-2291-6952)
- Benicio Noronha Frey (ORCID: https://orcid.org/0000-0001-8267-943X)
- Qiyong Gong (ORCID: https://orcid.org/0000-0002-5912-4871)
- Cherise Chin-Fatt (ORCID: https://orcid.org/0000-0001-5080-6799)
- Stefanie Hassel (ORCID: https://orcid.org/0000-0001-7240-1581)
- Kun Qin (ORCID: https://orcid.org/0000-0003-1254-6388)
- Ki Sueng Choi (ORCID: https://orcid.org/0000-0002-6446-0677)
- Ian Anderson (ORCID: https://orcid.org/0000-0003-2205-9209)
- W. Edward Craighead (ORCID: https://orcid.org/0000-0001-9957-0027)
- Madhukar H. Trivedi (ORCID: https://orcid.org/0000-0002-2983-1110)
- Martin P. Paulus (ORCID: https://orcid.org/0000-0002-0825-3606)
- Junhao Wen (ORCID: https://orcid.org/0000-0003-2077-3070)
- Heather C. Whalley (ORCID: https://orcid.org/0000-0002-4505-8869)
- José García (ORCID: https://orcid.org/0009-0000-2703-0777)
- Dhivya Srinivasan
- Matthew D. Sacchet (ORCID: https://orcid.org/0000-0002-8619-5237)
- Jiang Qiu
- Keith Ho
Institutions
- University of Copenhagen (DK)
- Hubei University of Medicine (CN)
- University Health Network (CA)
- Harvard University (US)
- Southwest University (CN)
- Emory University (US)
- University of East London (GB)
- University of Calgary (CA)
- University of California, San Francisco (US)
- King's College London (GB)
- University of Toronto (CA)
- Xiamen University (CN)
- South London and Maudsley NHS Foundation Trust (GB)
- Sichuan University (CN)
- Oxford Health NHS Foundation Trust (GB)
- Baycrest Hospital (CA)
- Edinburgh Cancer Research (GB)
- Rigshospitalet (DK)
- Edinburgh Royal Infirmary (GB)
- Warneford Hospital (GB)
- University of California System (US)
- University of Manchester (GB)
- University of Oxford (GB)
- Massachusetts General Hospital (US)
- West China Hospital of Sichuan University (CN)
- Circuit Therapeutics (United States) (US)
- Taihe Hospital (CN)
- Penn Center for AIDS Research (US)
- Centre for Global Health Research (CA)
- Capital Region of Denmark (DK)
- Laureate Institute for Brain Research (US)
- St. Joseph’s Healthcare Hamilton (CA)
- University of Pennsylvania (US)
- The University of Texas Southwestern Medical Center (US)
- Stanford University (US)
- McMaster University (CA)
- Icahn School of Medicine at Mount Sinai (US)
- Tsinghua University (CN)
Publication Details
- Journal
- Communications Medicine
- Published
- 2025-11-15
- DOI
- https://doi.org/10.1038/s43856-025-01219-5
- Citations
- 1
- Primary Topic
- Neurotransmitter Receptor Influence on Behavior
- Type
- article
- Field-Weighted Citation Impact
- 0.91
Funders
- National Alliance for Research on Schizophrenia and Depression
- Wellcome Trust
- LivaNova
- Michael Smith Health Research BC
- National Institute for Health and Care Research
- H. Lundbeck A/S
- Victoria General Hospital Foundation
- Canadian Institutes of Health Research
- Medical Research Council
- National Institute of Mental Health