DNA Helix Bundle‐Encoded Multi‐Bit Information Readout by Sapphire‐Supported Nanopores

Abstract The increasing demand for high‐capacity data storage continues to drive innovation in memory technologies. DNA has recently emerged as a promising medium due to its exceptionally high data density and long‐term stability. Here, a DNA‐based data storage and readout scheme is presented that leverages sapphire‐supported, low‐noise solid‐state nanopores for reliable detection of nanostructured DNA. Data are encoded onto four‐helix bundle (4HB) DNA structures, enabling flexible programmability and secure readout. The sapphire‐supported nanopores demonstrate a high signal‐to‐noise ratio (≈22) under a 250 kHz filtering frequency, allowing precise signal discrimination during readout. Using a decision‐tree supervised learning algorithm, up to ≈93% of encoded messages are accurately classified, demonstrating the feasibility of letter and message encoding for information retrieval. This work highlights the potential of integrating DNA nanostructures with low‐noise nanopore technology for high‐density, secure, and scalable data storage applications.

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Publication Details

Journal
Advanced Functional Materials
Published
2025-11-10
DOI
https://doi.org/10.1002/adfm.202523998
Primary Topic
Nanopore and Nanochannel Transport Studies
Type
article
Field-Weighted Citation Impact
0.00

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article

DNA Helix Bundle‐Encoded Multi‐Bit Information Readout by Sapphire‐Supported Nanopores

Abdulla Al Mamun, Ashif Ikbal, Rizal F. Hariadi, Xu Zhou et al.
Advanced Functional Materials
Nanopore and Nanochannel Transport Studies
article

DNA Helix Bundle‐Encoded Multi‐Bit Information Readout by Sapphire‐Supported Nanopores

Abdulla Al Mamun, Ashif Ikbal, Rizal F. Hariadi, Xu Zhou, Gde Bimananda Mahardika Wisna, Md Ashiqur Rahman Laskar, Pengkun Xia, Hao Yan, A. E. Krylova, Andrew Kemeklis, Chao Wang, Yinan Zhang, Deeksha Satyabola, Nimarpreet Kaur Bamrah
article en

Abstract

Abstract The increasing demand for high‐capacity data storage continues to drive innovation in memory technologies. DNA has recently emerged as a promising medium due to its exceptionally high data density and long‐term stability. Here, a DNA‐based data storage and readout scheme is presented that leverages sapphire‐supported, low‐noise solid‐state nanopores for reliable detection of nanostructured DNA. Data are encoded onto four‐helix bundle (4HB) DNA structures, enabling flexible programmability and secure readout. The sapphire‐supported nanopores demonstrate a high signal‐to‐noise ratio (≈22) under a 250 kHz filtering frequency, allowing precise signal discrimination during readout. Using a decision‐tree supervised learning algorithm, up to ≈93% of encoded messages are accurately classified, demonstrating the feasibility of letter and message encoding for information retrieval. This work highlights the potential of integrating DNA nanostructures with low‐noise nanopore technology for high‐density, secure, and scalable data storage applications.

Advanced Functional MaterialsVol. 36(24)
Tongji University (CN), Arizona State University (US), The University of Texas at Austin (US), Nanjing University (CN)
National Science Foundation, Arizona State University, National Institutes of Health, Eyring Materials Center, Arizona State University, Division of Electrical, Communications and Cyber Systems
Openalex Percentile: Top 66%
Nanopore and Nanochannel Transport Studies
DOIOpen Access PDFOpenAlex
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