Effectiveness of an Active Offer of Influenza Vaccination to Hospitalized Frail Patients

<b>Background/Objectives</b>: Following the COVID-19 pandemic, the influenza season returned to its typical pre-pandemic circulation patterns. The category of people most vulnerable to severe influenza was older adults, and frail individuals, confirming their central role as a priority group for vaccination. The objective of this study was to evaluate the impact of an active influenza vaccination program in an area with low influenza vaccination rates and propensity to vaccine co-administration. <b>Methods</b>: People recruited were hospitalized frail individuals, patients over the age of 60, and those with chronic illnesses or comorbidities. It was administered a questionnaire to investigate adherence to influenza vaccination and the Health Action Process Approach was used to evaluate the propensity to co-administration. <b>Results</b>: A total of 418 hospitalized patients were enrolled in the study, of whom 58.4% (n = 244) received the influenza vaccine and 17.9% (n = 75) had a higher propensity to have co-administration of influenza and other recommended vaccines. The factors associated with influenza vaccination acceptance were received advice from hospital healthcare workers (aOR = 10.6 <i>p</i> < 0.001) and previous influenza vaccination (aOR = 18.1; <i>p</i> < 0.001). Propensity to vaccine co-administration was associated with a higher educational level (aOR = 4.21; <i>p</i> = 0.002), receiving vaccination advice from hospital healthcare workers (aOR = 2.80; <i>p</i> = 0.03), perceived positive outcome (aOR = 1.29; <i>p</i> = 0.02) and perceived self-efficacy (aOR = 1.48; <i>p</i> < 0.001). Conslusions: This study explored the impact on influenza vaccination coverage in implementing in hospital vaccination offer. The reliability of this strategy, together with the standard vaccination offer, could allow reaching the recommended vaccination coverage, particularly among at-risk people.